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Merck
CN

T2320

Sigma-Aldrich

T0901317

≥98%

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别名:
N-(2,2,2-Trifluoroethyl)-N-[4-[2,2,2-trifluoro-1-hydroxy-1-(trifluoromethyl)ethyl]phenyl]-benzenesulfonamide
经验公式(希尔记法):
C17H12NSO3F9
分子量:
481.33
MDL编号:
UNSPSC代码:
12352200
PubChem化学物质编号:
NACRES:
NA.25

质量水平

检测方案

≥98%

分子量

481.3

储存温度

−20°C

SMILES字符串

OC(c1ccc(cc1)N(CC(F)(F)F)S(=O)(=O)c2ccccc2)(C(F)(F)F)C(F)(F)F

InChI

1S/C17H12F9NO3S/c18-14(19,20)10-27(31(29,30)13-4-2-1-3-5-13)12-8-6-11(7-9-12)15(28,16(21,22)23)17(24,25)26/h1-9,28H,10H2

InChI key

SGIWFELWJPNFDH-UHFFFAOYSA-N

基因信息

应用

T0901317应用于LXR激动剂研究,以观察小鼠所有受膳食胆固醇调节的基因的表达。此外,它还用于刺激WT(野生型)和Tg(转基因)小鼠放射性标记的腹腔巨噬细胞,以便进行细胞胆固醇流出测定。

生化/生理作用

T0901317能通过作用于线粒体代谢来阻止胰岛素的分泌。
LXR激动剂,其治疗导致ABC1基因表达的LXR依赖性上调

WGK

WGK 3

闪点(°F)

Not applicable

闪点(°C)

Not applicable

个人防护装备

Eyeshields, Gloves, type N95 (US)


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The LXR ligand T0901317 acutely inhibits insulin secretion by affecting mitochondrial metabolism
Maczewsky J, et al.
Endocrinology, 158(7), 2145-2154 (2017)
Differential Gene Regulation of StarD4 and StarD5 Cholesterol Transfer Proteins ACTIVATION OF StarD4 BY STEROL REGULATORY ELEMENT-BINDING PROTEIN-2 AND StarD5 BY ENDOPLASMIC RETICULUM STRESS
Soccio RE, et al.
The Journal of Biological Chemistry, 280(19), 19410-19418 (2005)
Yan Xing et al.
Scientific reports, 6, 21309-21309 (2016-02-19)
Liver X receptors (LXRs) play essential roles in lipogenesis, anti-inflammatory action and hepatic stellate cells (HSCs) activation in the liver. However, the effects of LXRs on the capillarization of liver sinusoidal endothelial cells (LSECs) in liver fibrosis remain undetermined. Here
Jahangir Iqbal et al.
Journal of lipid research, 59(11), 2084-2097 (2018-10-04)
Sphingolipids, including ceramide, SM, and hexosylceramide (HxCer), are carried in the plasma by lipoproteins. They are possible markers of metabolic diseases, but little is known about their control. We previously showed that microsomal triglyceride transfer protein (MTP) is critical to
Inhibition of local macrophage growth ameliorates focal inflammation and suppresses atherosclerosis
Yamada S, et al.
Arteriosclerosis, Thrombosis, and Vascular Biology, 38(5), 994-1006 (2018)

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