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Merck
CN
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文件

安全信息

T2252

Sigma-Aldrich

脱铁转铁蛋白 人

≥95% protein basis (biuret)

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别名:
人转铁蛋白, 铁传递蛋白
CAS号:
11096-37-0
EC 号:
234-318-8
MDL编号:
MFCD00130536
UNSPSC代码:
12352202
NACRES:
NA.61

生物来源

human

质量水平

200

检测方案

≥95% protein basis (biuret)
≥98% (agarose gel electrophoresis)

形式

powder

分子量

76-81 kDa

技术

cell culture | mammalian: suitable

溶解性

H2O: 50 mg/mL

UniProt登记号

P02787

运输

wet ice

储存温度

−20°C

基因信息

human ... TF(7018)

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一般描述

转铁蛋白是一种双叶糖蛋白，含有一个N端叶和一个N端叶。每个结构域被分为两个子结构域，在子结构域之间的间隙中是金属结合位点。一个转铁蛋白分子可以与两个铁离子结合。脱铁转铁蛋白呈现无铁形式。

应用

人脱铁转铁蛋白已用于杜氏改良Eagle培养基/营养混合物以培养：
  • 胰导管腺癌（PDAC）细胞系
  • 少突胶质细胞
  • 肾近端小管上皮细胞（RPTEC/TERT1）

转铁蛋白可以强烈抑制细菌与生物材料的粘附，包括聚苯乙烯、聚甲基丙烯酸甲酯和硅氧烷。在培养基中，20 ug/ml 可以观察到抑制作用 。

生化/生理作用

转铁蛋白通过受体介导的内吞作用运输铁。铁转运机制发生在血脑屏障的内皮细胞中。转铁蛋白维持铁稳态，是一种铁相关标记物。重症COVID-19中观察到转铁蛋白水平下降。它可以与铁以外的其他分子结合，因此可以用于靶向药物输送。

其他说明

非血红素铁转运蛋白。

免责声明

供研究使用在法国，在用于科研目的时（包括进口和出口活动（《公共健康法》第L 1211-1条，第2节））该产品为管制品。购买者（即最终用户）需要获得《公共健康法》法第L 1211-1条规定的法国研究部的进口授权。订购本产品即表明您确认已经获得合适的进口授权。

WGK

WGK 3

法规信息

常规特殊物品

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  1. Which document(s) contains shelf-life or expiration date information for a given product?

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  5. What is the carbohydrate content of human transferrin?

    We have found the information on transferrin in a reference book:The Plasma Proteins, F.W. Putnam, ed, volume 2, chapter 4, Table II.According to the table, Transferrin is 6 percent carbohydrate, citing G.A. Jamieson, J. Biol. Chem. 240(7), 2914-2920 (1965).The table also gives information on the percentage of each type of monosaccharide that is present.

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