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Merck
CN
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文件

安全信息

T2036

Sigma-Aldrich

脱铁转铁蛋白 人

powder, BioReagent, suitable for cell culture, ≥98% (agarose gel electrophoresis)

别名:

人转铁蛋白, 铁传递蛋白

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About This Item

CAS号:
11096-37-0
EC 号:
234-318-8
MDL编号:
MFCD00130536
UNSPSC代码:
12352202
NACRES:
NA.75

产品线

BioReagent

质量水平

200

检测方案

≥98% (agarose gel electrophoresis)

形式

powder

分子量

76-81 kDa

浓度

~25 mM

技术

cell culture | mammalian: suitable

杂质

HIV and HBsAg, source material tested negative
 endotoxin, tested

溶解性

H2O: 50 mg/mL

痕量阳离子

Fe: ≤0.005%

UniProt登记号

P02787

运输

ambient

储存温度

−20°C

基因信息

human ... TF(7018)

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相关类别

一般描述

转铁蛋白主要在肝脏中合成，是血清中含量丰富的糖蛋白。转铁蛋白超家族成员具有相似的多肽折叠模式。转铁蛋白含有N端和C端铁结合同源结构域。这些结构域中的每一个都被分裂成两个子结构域，在子结构域间隙内具有铁和阴离子的结合位点。绑定间隙随着铁释放和铁绑定打开和关闭。脱铁转铁蛋白是一种无铁蛋白，在转铁蛋白与其受体分离后产生。此产物可以补充铁或用于结合培养基中存在的游离铁。

应用

脱铁转铁蛋白已用于：
  • 培养人原代胰腺内皮细胞、Het1As（非肿瘤食管细胞）和永生化人结肠上皮细胞（HCEC-1CT）
  • 培养α小鼠肝12（AML-12）（成熟肝细胞）细胞
  • 作为晶体学前纯化的人脱铁转铁蛋白的来源

生化/生理作用

转铁蛋白负责将铁从吸收和储存的部位运送到组织细胞。它能维持生物体液中的铁含量。转铁蛋白的水平可以反映总铁结合能力（TIBC）。转铁蛋白为骨髓中红细胞的血红蛋白提供所需的铁元素。缺铁会导致转铁蛋白水平升高。怀孕和服用雌激素也会提高转铁蛋白的水平。慢性肝病、肾功能不全、营养不良和蛋白质丢失性肠病会减少转铁蛋白的合成。

其他说明

非血红素铁转运蛋白。

免责声明

供研究使用在法国，在用于科研目的时（包括进口和出口活动（《公共健康法》第L 1211-1条，第2节））该产品为管制品。购买者（即最终用户）需要获得《公共健康法》法第L 1211-1条规定的法国研究部的进口授权。订购本产品即表明您确认已经获得合适的进口授权。

WGK

WGK 3

法规信息

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  5. What is the carbohydrate content of human transferrin?

    We have found the information on transferrin in a reference book:The Plasma Proteins, F.W. Putnam, ed, volume 2, chapter 4, Table II.According to the table, Transferrin is 6 percent carbohydrate, citing G.A. Jamieson, J. Biol. Chem. 240(7), 2914-2920 (1965).The table also gives information on the percentage of each type of monosaccharide that is present.

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