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一般描述
Transferrin is a bilobed glycoprotein. The polypeptide chain of transferrin is composed of two homologous lobes i.e N- and C- lobes. Each lobe is made of two domains N1, N2 and C1, C2 which are linked by a hinge. It has two specific sites for binding of Fe3+.
应用
Anti-Transferrin antibody has been used:
- in quantitative precipitin assay
- in enzyme linked immunosorbent assay (ELISA)
- in western blotting
- in immunoblotting
Anti-Transferrin antibody produced in goat was used in western blotting analysis of HEK293 cell extracts.
生化/生理作用
Transferrin is the major iron transporter protein that binds Fe(+3). The transferring-iron import system consists of a TonB dependent transporter (TbpA), and a lipoprotein co-receptor (TbpB) and both proteins work together in the transport of iron across the membrane.
Transferrin plays a major role in providing iron as a source for haemoglobin synthesis. It binds to the transferrin receptor 1(TfR1).
制备说明
treated to remove lipoproteins
免责声明
Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
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储存分类代码
10 - Combustible liquids
WGK
WGK 3
闪点(°F)
Not applicable
闪点(°C)
Not applicable
个人防护装备
Eyeshields, Gloves, multi-purpose combination respirator cartridge (US)
法规信息
常规特殊物品
历史批次信息供参考:
分析证书(COA)
Lot/Batch Number
Receptor-mediated activation of a proinsulin-transferrin fusion protein in hepatoma cells.
Wang, Y., et al.
J. Controlled Release, 155, 386-392 (2011)
Hypoglycosylation is a common finding in antithrombin deficiency in the absence of a SERPINC 1 gene defect
de la Morena-Barrio M E, et al.
Journal of Thrombosis and Haemostasis, 14(8), 1549-1560 (2016)
Cole P Anderson et al.
Biochimica et biophysica acta, 1823(9), 1468-1483 (2012-05-23)
Cellular iron homeostasis is maintained by iron regulatory proteins 1 and 2 (IRP1 and IRP2). IRPs bind to iron-responsive elements (IREs) located in the untranslated regions of mRNAs encoding protein involved in iron uptake, storage, utilization and export. Over the
Yan Wang et al.
Journal of controlled release : official journal of the Controlled Release Society, 155(3), 386-392 (2011-07-16)
A proinsulin-transferrin (ProINS-Tf) recombinant fusion protein was designed and characterized for the sustained release of an active form of insulin (INS) by hepatoma cells. During incubation with H4IIE hepatoma cells, a gradual decline of ProINS-Tf concentration, with a concomitant generation
New iron acquisition system in Bacteroidetes
Manfredi P, et al.
Infection and Immunity, 83(1), 300-310 (2015)
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