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Merck
CN

T182

酪氨酸激酶抑制剂A9

solid

别名:

Malonoben, [[3,5-bis(1,1-Dimethylethyl)-4-hydroxyphenyl]methylene]propanedinitrile

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关于此项目

经验公式（希尔记法）:
C18H22N2O
化学文摘社编号:
10537-47-0
分子量:
282.38
MDL编号:
MFCD00209853
UNSPSC代码:
51111800
PubChem化学物质编号:
24278069
NACRES:
NA.77

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生物来源

synthetic (organic)

质量水平

100

方案

≥98% (HPLC)

表单

solid

颜色

yellow

mp

139-140 °C

溶解性

ethanol: 20 mg/mL
DMSO: <25 mg/mL
H2O: insoluble

SMILES字符串

CC(C)(C)c1cc(\C=C(\C#N)C#N)cc(c1O)C(C)(C)C

InChI

1S/C18H22N2O/c1-17(2,3)14-8-12(7-13(10-19)11-20)9-15(16(14)21)18(4,5)6/h7-9,21H,1-6H3

InChI key

MZOPWQKISXCCTP-UHFFFAOYSA-N

基因信息

human ... EGFR(1956), ORAI1(84876), PDGFRA(5156), PDGFRB(5159)
mouse ... Eef2k(13631), Prkaca(18747), Prkca(18750), Src(20779)

相关类别

应用

Tyrphostin A9 can be used for inhibiting tyrosine kinase functions in C2C12 cells. It has also been used to disrupt membrane potential in mammalian cells.

生化/生理作用

Tyrphostin A9 is a PDGF receptor tyrosine kinase inhibitor that can induce apoptosis in cancer cells, inhibit the growth of vascular smooth cells and block calcium release-dependent phosphorylations.

特点和优势

This compound is a featured product for Kinase Phosphatase Biology research. Click here to discover more featured Kinase Phosphatase Biology products. Learn more about bioactive small molecules for other areas of research at sigma.com/discover-bsm.

制备说明

Tyrphostin A9 is soluble in ethanol at 20 mg/ml, in DMSO at a concentration less than 25 mg/ml. It is insoluble in water.

象形图

Skull and crossbones
GHS06

警示用语：

Danger

危险声明

H301 + H311

危险分类

Acute Tox. 3 Dermal - Acute Tox. 3 Oral

储存分类代码

6.1C - Combustible acute toxic Cat.3 / toxic compounds or compounds which causing chronic effects

WGK

WGK 3

闪点(°F)

Not applicable

闪点(°C)

Not applicable

个人防护装备

Eyeshields, Faceshields, Gloves, type P2 (EN 143) respirator cartridges

法规信息

农药列管产品
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历史批次信息供参考:

分析证书(COA)

Lot/Batch Number
MKCV7328
MKCT9315
MKCS3755
MKCR8771
MKCH0037

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J Thyberg
European journal of cell biology, 76(1), 33-42 (1998-07-03)
To proliferate, vascular smooth muscle cells first convert from a contractile to a synthetic phenotype. Earlier studies indicate that this process is supported by fibronectin and accelerated by platelet-derived growth factor (PDGF). Here, the mechanisms in this transition were further
So Jung Park et al.
Biochemical and biophysical research communications, 408(3), 465-470 (2011-04-30)
Mitochondria dynamics controls not only their morphology but also functions of mitochondria. Therefore, an imbalance of the dynamics eventually leads to mitochondria disruption and cell death. To identify specific regulators of mitochondria dynamics, we screened a bioactive chemical compound library
Naveen Kumar et al.
Journal of virology, 85(6), 2818-2827 (2011-01-07)
Host signaling pathways play important roles in the replication of influenza virus, but their functional effects remain to be characterized at the molecular level. Here we identify two receptor tyrosine kinase inhibitors (RTKIs) of the tyrphostin class that exhibit robust
Naveen Kumar et al.
Antimicrobial agents and chemotherapy, 55(12), 5553-5559 (2011-09-21)
We have previously reported that two receptor tyrosine kinase inhibitors (RTKIs), called AG879 and tyrphostin A9 (A9), can each block the replication of influenza A virus in cultured cells. In this study, we further characterized the in vitro antiviral efficacies
M Zhao et al.
Leukemia, 14(3), 374-378 (2000-03-17)
Somatic mutation of the FLT3 gene, in which the juxtamembrane domain has an internal tandem duplication, is found in 20% of human acute myeloid leukemias and causes constitutive tyrosine phosphorylation of the products. In this study, we observed that the
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