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Merck
CN
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文件

安全信息

T1775

Sigma-Aldrich

L-甲状腺素

powder, BioReagent, suitable for cell culture

别名:

3,3′,5,5″-四碘代-L-甲状腺原氨酸, 3-[4-(4-羟基-3,5-二碘苯氧基)-3,5-二碘苯基]-L-丙氨酸, T4

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About This Item

线性分子式:
HOC6H2(I)2OC6H2(I)2CH2CH(NH2)CO2H
CAS号:
51-48-9
分子量:
776.87
Beilstein:
2228515
EC 号:
200-101-1
MDL编号:
MFCD00002595
UNSPSC代码:
12352209
eCl@ss:
32190102
PubChem化学物质编号:
24899990
NACRES:
NA.77

生物来源

synthetic

质量水平

200

产品线

BioReagent

检测方案

≥98% (HPLC)

形式

powder

效能

5-50 ng/mL

技术

cell culture | mammalian: suitable

mp

223 °C (dec.) (lit.)

溶解性

4 M NH4OH in methanol: 50 mg/mL, clear to hazy, yellow

运输

ambient

储存温度

room temp

SMILES字符串

N[C@@H](Cc1cc(I)c(Oc2cc(I)c(O)c(I)c2)c(I)c1)C(O)=O

InChI

1S/C15H11I4NO4/c16-8-4-7(5-9(17)13(8)21)24-14-10(18)1-6(2-11(14)19)3-12(20)15(22)23/h1-2,4-5,12,21H,3,20H2,(H,22,23)/t12-/m0/s1

InChI key

XUIIKFGFIJCVMT-LBPRGKRZSA-N

基因信息

human ... THRA(7067) , THRB(7068) , TTR(7276)
mouse ... Cnr2(12802)
rat ... Cnr1(25248)

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相关类别

一般描述

Thyroxine (T4) is a tetraiodo derivative of the p-hydroxyphenyl ether of tyrosine, which functions as growth factors or cell growth inhibitors. T4 is used to treat hypothyroidism and thyroid carcinoma. It regulates energy metabolism.

应用

L-Thyroxine has been used to investigate its role in colorectal cancer cell lines HCT 116 (APC wild type) and HT-29 (APC mutant). It has also been used to evaluate its effects on pro-inflammatory tumor necrosis factor-α (TNF-α), interleukin-6 (IL-6), angiogenic vascular endothelial growth factor (VEGF), leukocyte adhesion, intercellular adhesion molecule 1 (ICAM-1) and E-selectin in human umbilical vein endothelial cells (HUVECs).

生化/生理作用

L甲状腺素 (T4) 和三碘代-L-甲状腺原氨酸 (T3) 为含碘激素，由甲状腺卵泡细胞中的甲状腺球蛋白制备。这些激素对代谢率的刺激以及对生长发展的调节似乎归因于它们对 DNA 转录的作用，进而影响蛋白质的合成。

制备说明

For long term storage, keep stock solutions at -20° in working aliquots and avoid repeated freeze/thaw cycles. Solutions stored at 2-8 °C are stable for up to 30 days.

重悬

To prepare 20 μg/ml stock solution, dissolve in 50 ml sterile culture medium per mg thyroxine.

象形图

Health hazard
GHS08

警示用语：

Danger

危险声明

H372

危险分类

STOT RE 1

靶器官

Thyroid,Cardio-vascular system,Kidney

储存分类代码

6.1C - Combustible acute toxic Cat.3 / toxic compounds or compounds which causing chronic effects

WGK

WGK 3

闪点(°F)

Not applicable

闪点(°C)

Not applicable

个人防护装备

Eyeshields, Gloves, type N95 (US)

法规信息

监管及禁止进口产品

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访问文档库

Thyroid hormones (T3 and T4): dual effect on human cancer cell proliferation
Moriggi G, et al.
Anticancer Research, 31(1), 89-96 (2011)
Effects of thyroid-stimulating hormone on adhesion molecules and pro-inflammatory cytokines secretion in human umbilical vein endothelial cells
Milani AT, et al.
Research in Pharmaceutical Sciences, 13(6), 546-546 (2018)
Effects of thyroxine as compared with thyroxine plus triiodothyronine in patients with hypothyroidism
Bunevivcius R, et al.
The New England Journal of Medicine, 340(6), 424-429 (1999)
Thyroid hormone promotes beta-catenin activation and cell proliferation in colorectal cancer
Lee YS, et al.
Hormones & Cancer, 9(3), 156-165 (2018)
Thyroxine therapy
Toft AD
The New England Journal of Medicine, 331(3), 174-180 (1994)
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