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Merck
CN

T1775

L-甲状腺素

powder, BioReagent, suitable for cell culture

别名:

3,3′,5,5″-四碘代-L-甲状腺原氨酸, 3-[4-(4-羟基-3,5-二碘苯氧基)-3,5-二碘苯基]-L-丙氨酸, T4

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关于此项目

线性分子式:
HOC6H2(I)2OC6H2(I)2CH2CH(NH2)CO2H
化学文摘社编号:
51-48-9
分子量:
776.87
NACRES:
NA.77
PubChem Substance ID:
24899990
eCl@ss:
32190102
UNSPSC Code:
12352209
EC Number:
200-101-1
MDL number:
MFCD00002595
Beilstein/REAXYS Number:
2228515
Biological source:
synthetic
Form:
powder
Assay:
≥98% (HPLC)

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产品名称

L-甲状腺素, powder, BioReagent, suitable for cell culture

InChI key

XUIIKFGFIJCVMT-LBPRGKRZSA-N

InChI

1S/C15H11I4NO4/c16-8-4-7(5-9(17)13(8)21)24-14-10(18)1-6(2-11(14)19)3-12(20)15(22)23/h1-2,4-5,12,21H,3,20H2,(H,22,23)/t12-/m0/s1

SMILES string

N[C@@H](Cc1cc(I)c(Oc2cc(I)c(O)c(I)c2)c(I)c1)C(O)=O

biological source

synthetic

product line

BioReagent

assay

≥98% (HPLC)

form

powder

potency

5-50 ng/mL

technique(s)

cell culture | mammalian: suitable

mp

223 °C (dec.) (lit.)

solubility

4 M NH4OH in methanol: 50 mg/mL, clear to hazy, yellow

shipped in

ambient

storage temp.

room temp

Quality Level

200

Gene Information

human ... THRA(7067), THRB(7068), TTR(7276)
mouse ... Cnr2(12802)
rat ... Cnr1(25248)

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相关类别

Biochem/physiol Actions

L甲状腺素 (T4) 和三碘代-L-甲状腺原氨酸 (T3) 为含碘激素，由甲状腺卵泡细胞中的甲状腺球蛋白制备。这些激素对代谢率的刺激以及对生长发展的调节似乎归因于它们对 DNA 转录的作用，进而影响蛋白质的合成。

Application

L-Thyroxine has been used to investigate its role in colorectal cancer cell lines HCT 116 (APC wild type) and HT-29 (APC mutant). It has also been used to evaluate its effects on pro-inflammatory tumor necrosis factor-α (TNF-α), interleukin-6 (IL-6), angiogenic vascular endothelial growth factor (VEGF), leukocyte adhesion, intercellular adhesion molecule 1 (ICAM-1) and E-selectin in human umbilical vein endothelial cells (HUVECs).

General description

Thyroxine (T4) is a tetraiodo derivative of the p-hydroxyphenyl ether of tyrosine, which functions as growth factors or cell growth inhibitors. T4 is used to treat hypothyroidism and thyroid carcinoma. It regulates energy metabolism.

Preparation Note

For long term storage, keep stock solutions at -20° in working aliquots and avoid repeated freeze/thaw cycles. Solutions stored at 2-8 °C are stable for up to 30 days.
To prepare 20 μg/ml stock solution, dissolve in 50 ml sterile culture medium per mg thyroxine.

pictograms

Health hazard
GHS08

signalword

Danger

hcodes

H372

Hazard Classifications

STOT RE 1

target_organs

Thyroid,Cardio-vascular system,Kidney

存储类别

6.1C - Combustible acute toxic Cat.3 / toxic compounds or compounds which causing chronic effects

wgk

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

ppe

Eyeshields, Gloves, type N95 (US)

法规信息

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历史批次信息供参考:

分析证书(COA)

Lot/Batch Number
BCCP0039
BCCM6294
BCCK9809
BCCJ6599
BCCH3589

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Thyroid hormone promotes beta-catenin activation and cell proliferation in colorectal cancer
Lee YS, et al.
Hormones & Cancer, 9(3), 156-165 (2018)
The
Clinical Chemistry, 331(3), 174-180 (2008)
Effects of thyroxine as compared with thyroxine plus triiodothyronine in patients with hypothyroidism
Bunevivcius R, et al.
The New England Journal of Medicine, 340(6), 424-429 (1999)
Thyroxine therapy
Toft AD
The New England Journal of Medicine, 331(3), 174-180 (1994)
Chemistry of thyroxine. III. Constitution and synthesis of thyroxine
Harrington CR and Barger G
The Biochemical Journal, 21(6), 169-183 (1927)
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