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T1694

(E)-4-Amino-2-butenoic acid

Name: (E)-4-Amino-2-butenoic acid
Brand: SIGMA

别名:

trans-4-Aminocrotonic acid, TACA

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About This Item

经验公式（希尔记法）:

C₄H₇NO₂

CAS号:

25747-40-4

分子量:

101.10

MDL编号:

MFCD00673818

UNSPSC代码:

12352106

PubChem化学物质编号:

24278194

NACRES:

NA.77

形式

powder

颜色

white

溶解性

H₂O: 10 mg/mL, clear

SMILES字符串

NC\C=C\C(O)=O

InChI

1S/C4H7NO2/c5-3-1-2-4(6)7/h1-2H,3,5H2,(H,6,7)/b2-1+

InChI key

FMKJUUQOYOHLTF-OWOJBTEDSA-N

WGK

WGK 3

闪点(°F)

Not applicable

闪点(°C)

Not applicable

个人防护装备

Eyeshields, Gloves, type N95 (US)

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Effect of GABA-ergic mechanisms on synaptosomal NO synthesis and the nitrergic component of NANC relaxation in rat ileum.

M Kurjak et al.

Neurogastroenterology and motility : the official journal of the European Gastrointestinal Motility Society, 23(5), e181-e190 (2011-03-19)

γ-Aminobutyric acid (GABA) acts on specific neural receptors [A, B and C(Aρ)] to modulate gastrointestinal function. The precise role of GABA receptor activation in the regulation of presynaptic nitric oxide (NO) synthesis in nerve terminals is unknown. Rat ileal nerve

Effects of a metabotropic glutamate 1 receptor antagonist on light responses of retinal ganglion cells in a rat model of retinitis pigmentosa.

Ralph J Jensen

PloS one, 8(10), e79126-e79126 (2013-11-10)

Retinitis pigmentosa (RP) is a progressive retinal degenerative disease that causes deterioration of rod and cone photoreceptors. A well-studied animal model of RP is the transgenic P23H rat, which carries a mutation in the rhodopsin gene. Previously, I reported that

Trans-4-aminocrotonic acid (TACA), a potent agonist of GABA(A) and GABA(C) receptors, shows a proconvulsant action in the electroconvulsive threshold test in mice.

Kinga K Borowicz et al.

Pharmacological reports : PR, 57(1), 121-123 (2005-04-26)

In the present study, we evaluated TACA (a potent agonist of GABA(A) and GABA(C) receptors) in the electroconvulsive threshold test in mice. Surprisingly, TACA (at 15 and 25 mg/kg) significantly decreased the threshold. The highest ineffective dose of TACA was

Structure and function of GABA(C) receptors: a comparison of native versus recombinant receptors.

D Zhang et al.

Trends in pharmacological sciences, 22(3), 121-132 (2001-03-10)

In less than a decade our knowledge of the GABA(C) receptor, a new type of Cl(-)-permeable ionotropic GABA receptor, has greatly increased based on studies of both native and recombinant receptors. Careful comparison of properties of native and recombinant receptors

Analogues of gamma-aminobutyric acid (GABA) and trans-4-aminocrotonic acid (TACA) substituted in the 2 position as GABAC receptor antagonists.

M Chebib et al.

British journal of pharmacology, 122(8), 1551-1560 (1998-01-10)

1. gamma-Aminobutyric acid (GABA) and trans-4-aminocrotonic acid (TACA) have been shown to activate GABAC receptors. In this study, a range of C2, C3, C4 and N-substituted GABA and TACA analogues were examined for activity at GABAC receptors. 2. The effects

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