推荐产品
方案
≥98% (HPLC)
质量水平
表单
solid
储存条件
desiccated
颜色
white to off-white
溶解性
DMSO: ≥20 mg/mL
H2O: soluble
ethanol: moderately soluble
SMILES字符串
Cl.OC1(CCN(CCCC(=O)c2ccc(F)cc2)CC1)c3cccc(c3)C(F)(F)F
InChI
1S/C22H23F4NO2.ClH/c23-19-8-6-16(7-9-19)20(28)5-2-12-27-13-10-21(29,11-14-27)17-3-1-4-18(15-17)22(24,25)26;/h1,3-4,6-9,15,29H,2,5,10-14H2;1H
InChI key
VYGQXRZAHIZHQV-UHFFFAOYSA-N
基因信息
human ... DRD1(1812) , DRD2(1813) , DRD3(1814) , DRD4(1815) , DRD5(1816)
应用
The interaction of Trifluperidol hydrochloride with NMDA receptors was studied in rat brain buffy coat membranes.
生化/生理作用
Trifluperidol is a dopamine receptor antagonist with antipsychotic effects used in the treatment of schizophrenia. This neuroleptic penetrates the brain and also affects the glial cells leading to increased release of proinflammatory cytokines. It also alters the metabolism of carbohydrates and amino acids in the brain cortex.
警示用语：
Danger
危险声明
危险分类
Acute Tox. 3 Oral
储存分类代码
6.1C - Combustible acute toxic Cat.3 / toxic compounds or compounds which causing chronic effects
WGK
WGK 3
闪点(°F)
Not applicable
闪点(°C)
Not applicable
个人防护装备
Eyeshields, Faceshields, Gloves, type P2 (EN 143) respirator cartridges
法规信息
新产品
从最新的版本中选择一种：
分析证书(COA)
Lot/Batch Number
H Michalek et al.
The Biochemical journal, 110(2), 237-241 (1968-11-01)
1. The effect of triperidol on the metabolism of glucose, pyruvate, glutamate, aspartate and glycine was studied with rat brain-cortex slices, U-(14)C-labelled substrates and a quantitative radiochromatographic technique. 2. Triperidol at a concentration of 0.2mm decreased the oxygen uptake and
J Kowalski et al.
Polish journal of pharmacology, 56(5), 563-570 (2004-12-14)
Neuroleptics penetrate into the brain, where they act not only on neurons but probably also on glial cells. In the available literature, there are no reports on the effect of neuroleptics on cytokine release in glia cultures. The aim of
L L Coughenour et al.
The Journal of pharmacology and experimental therapeutics, 296(1), 150-159 (2000-12-21)
The use of trifluoroperazine in a well washed rat brain membrane preparation revealed [(3)H]ifenprodil binding to a single high affinity state with the pharmacology of N-methyl-D-aspartate (NMDA) receptors containing NR2B subunits. Inhibition of [(3)H]ifenprodil binding in the presence of trifluoroperazine
K Herrick-Davis et al.
The Journal of pharmacology and experimental therapeutics, 295(1), 226-232 (2000-09-19)
Clozapine is the prototype atypical antipsychotic drug, producing little or no extrapyramidal side effects, while improving negative symptoms of psychosis. Clozapine's high affinity for serotonin receptors has been hypothesized to confer the unique antipsychotic properties of this drug. Recently, we
Lisa Burry et al.
The Cochrane database of systematic reviews, 6, CD005594-CD005594 (2018-06-20)
Guidelines suggest limited and cautious use of antipsychotics for treatment of delirium where nonpharmacological interventions have failed and symptoms remain distressing or dangerous, or both. It is unclear how well these recommendations are supported by current evidence. Our primary objective
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