T0318
曲尼司特
≥98% (HPLC), LTC4 inhibitor, powder
别名:
2-[[3-（3,4-二甲氧基苯基）-1-氧代-2-丙烯基] 氨基] 苯甲酸, 3,4-DAA, N-（3,4-二甲氧基肉桂酰）邻氨基苯甲酸, SB-252218, 利喘平
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关于此项目
经验公式（希尔记法）:
C18H17NO5
化学文摘社编号:
分子量:
327.33
UNSPSC Code:
41106500
PubChem Substance ID:
NACRES:
NA.77
MDL number:
产品名称
曲尼司特, ≥98% (HPLC), powder
SMILES string
COc1ccc(\C=C\C(=O)Nc2ccccc2C(O)=O)cc1OC
InChI key
NZHGWWWHIYHZNX-CSKARUKUSA-N
InChI
1S/C18H17NO5/c1-23-15-9-7-12(11-16(15)24-2)8-10-17(20)19-14-6-4-3-5-13(14)18(21)22/h3-11H,1-2H3,(H,19,20)(H,21,22)/b10-8+
assay
≥98% (HPLC)
form
powder
color
white to beige
mp
166.2-168.2 °C (lit.)
solubility
DMSO: >10 mg/mL
H2O: insoluble
originator
Kissei
storage temp.
2-8°C
Quality Level
Gene Information
human ... VEGFA(7422), VEGFB(7423), VEGFC(7424)
Application
在小鼠骨髓来源的肥大细胞中研究了曲尼司特对肥大细胞表面受体的作用。
Biochem/physiol Actions
曲尼司特是一种抗哮喘药物，可抑制刺激单核细胞 LTC 4 和 PGE 2 的形成，但不抑制环氧合酶或脂氧合酶活性；抑制肥大细胞脱颗粒；在体内抑制 VEGF 诱导的血管生成 ，在体外也抑制人内皮细胞的增殖和管道形成 。曲尼司特可能代表一类新的治疗 T H 1 介导的自身免疫性疾病的药物。
曲尼司特是一种抗哮喘药物，抑制刺激的单核细胞 LTC 4 和 PGE 2 的形成，抑制肥大细胞脱颗粒，并抑制体内 VEGF 诱导的血管生成，也抑制体外人内皮细胞的增殖和成管。
曲尼司特还通过抑制细胞周期蛋白依赖性激酶抑制剂-1（p21Waf1 / Cip1）来抑制血管平滑肌细胞的增殖，它可用于治疗心脏同种异体移植物血管病变（cardiac allograft vasculopathy）。它用于治疗肥厚性瘢痕和瘢痕疙瘩。曲尼司特会抑制肿瘤坏死因子（TNF-α和TGF-β2），从而阻碍人视网膜色素上皮细胞系（ARPE）的上皮间质转化。
signalword
Warning
hcodes
Hazard Classifications
Acute Tox. 4 Oral
存储类别
11 - Combustible Solids
wgk
WGK 3
ppe
dust mask type N95 (US), Eyeshields, Gloves
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