SRP8014
Progranulin human
>95% (SDS-PAGE), recombinant, expressed in HEK 293 cells, lyophilized
别名:
Activation-inducible TNF-related ligand, PEPI, Proepithelin
产品名称
Progranulin human, recombinant, expressed in HEK 293 cells, untagged, >95% (SDS-PAGE)
biological source
human
recombinant
expressed in HEK 293 cells
conjugate
untagged
assay
>95% (SDS-PAGE)
form
lyophilized
mol wt
~65 kDa by SDS-PAGE
packaging
pkg of 10 μg
storage condition
avoid repeated freeze/thaw cycles
impurities
<0.1 EU/μg endotoxin, tested
color
white
UniProt accession no.
shipped in
wet ice
storage temp.
−20°C
Gene Information
human ... GRN(2896)
Preparation Note
Reconstitute with 100 μL deionized water.
Biochem/physiol Actions
Progranulin (PGRN) is a widely expressed pluripotent growth factor, which plays a crucial role in various processes such as development, cell cycle progression, cell motility, wound repair and inflammation. Additionally, It is also implicated in early embryogenesis, host defense, cartilage development and degradation. Mutations in the PGRN gene were found in cases of frontotemporal degeneration (FTLD). PGRN expression is associated with the development of various type of cancer such as breast cancer, ovarian carcinoma, and multiple myeloma. Overexpression of PGRN has been observed in neurodegenerative diseases such as microglia of Creutzfeldt-Jacob patients and in spinal cord of amyotrophic lateral sclerosis (ALS) patients.
General description
Progranulin (PGRN) is a cysteine-rich protein with 593-amino acids and has a molecular weight of ~68.5kDa. The PGRN gene, with one non-coding exon and 12 coding exons spanning 8kb of genomic DNA, is mapped to human chromosome 17q21. The encoded protein is characterized by seven granulin-like domains, which include 7.5 highly conserved tandem repeats of a rare 12 cysteinyl residues. PGRN is predominantly expressed in rapidly cycling epithelial cells, leukocytes, neurons, and chondrocytes.
Other Notes
Signal peptide and human progranulin (aa 1-593) is untagged. Reflects the native sequence with no additional aa.
Physical form
Lyophilized from 0.2 μm-filtered solution in PBS.
存储类别
10 - Combustible liquids
wgk
WGK 2
flash_point_f
Not applicable
flash_point_c
Not applicable
法规信息
新产品
此项目有
Mutations other than null mutations producing a pathogenic loss of progranulin in frontotemporal dementia.
van der Zee J
Human Mutation, 28(4), 416-416 (2007)
Progranulin in neurodegenerative disease.
Petkau TL and Leavitt BR2
Trends in Neurosciences, 37(7), 388-398 (2014)
The growth factor progranulin binds to TNF receptors and is therapeutic against inflammatory arthritis in mice.
Tang W
Science, 332(6028), 478-484 (2011)
Progranulin in frontotemporal lobar degeneration and neuroinflammation.
Ahmed Z
Journal of Neuroinflammation (2007)
Lorenz Thurner et al.
Digestive diseases and sciences, 59(8), 1733-1742 (2014-03-05)
Recently, we identified neutralizing autoantibodies against progranulin (PGRN) in a wide spectrum of rheumatic diseases including cases with enteropathic spondylarthritis. PGRN is a secreted protein with strong anti-inflammatory effects, believed to be mediated by the direct inhibition of TNF receptors
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