重组
expressed in E. coli
方案
≥70% (SDS-PAGE)
表单
buffered aqueous glycerol solution
比活
1799-2435 nmol/min·mg
分子量
~96 kDa
NCBI登记号
运输
dry ice
储存温度
−70°C
基因信息
human ... PTPRA(5786)
一般描述
PTPRA (also known as LRP) is a member of the protein tyrosine phosphatase family and contains an extracellular domain, a single transmembrane segment and two tandem intracytoplasmic catalytic domains. PTPRA dephosphorylates SRC family kinases, potassium channels and NMDA receptors and exists as three alternatively spliced variants which encode two distinct isoforms. Absence of PTPRA compromises correct positioning of pyramidal neurons during development of mouse hippocampus.
外形
Supplied in 50mM Tris-HCl, pH 7.5, 150mM NaCl, 10mM glutathione, 0.1mM EDTA, 0.25mM DTT, 0.1mM PMSF, 25% glycerol.
制备说明
after opening, aliquot into smaller quantities and store at -70 °C. Avoid repeating handling and multiple freeze/thaw cycles
储存分类代码
10 - Combustible liquids
WGK
WGK 1
闪点(°F)
Not applicable
闪点(°C)
Not applicable
法规信息
新产品
R J Matthews et al.
Proceedings of the National Academy of Sciences of the United States of America, 87(12), 4444-4448 (1990-06-01)
Protein-tyrosine-phosphatases (protein-tyrosine-phosphate phosphohydrolase, EC 3.13.48) have been implicated in the regulation of cell growth; however, to date few tyrosine phosphatases have been characterized. To identify additional family members, the cDNA for the human tyrosine phosphatase leukocyte common antigen (LCA; CD45)
Angiola Petrone et al.
The EMBO journal, 22(16), 4121-4131 (2003-08-13)
Despite clear indications of their importance in lower organisms, the contributions of protein tyrosine phosphatases (PTPs) to development or function of the mammalian nervous system have been poorly explored. In vitro studies have indicated that receptor protein tyrosine phosphatase alpha
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