SRP0351
PDGFRb active human
recombinant, expressed in baculovirus infected Sf9 cells, ≥70% (SDS-PAGE)
别名:
CD140B, JTK12, platelet-derived growth factor receptor, beta polypeptide
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关于此项目
Form:
aqueous solution
Assay:
≥70% (SDS-PAGE)
Biological source:
human
Recombinant:
expressed in baculovirus infected Sf9 cells
Mol wt:
62 kDa
产品名称
PDGFRb active human, recombinant, expressed in baculovirus infected Sf9 cells, ≥70% (SDS-PAGE)
biological source
human
recombinant
expressed in baculovirus infected Sf9 cells
assay
≥70% (SDS-PAGE)
form
aqueous solution
mol wt
62 kDa
packaging
pkg of 10 μg
technique(s)
activity assay: suitable
inhibition assay: suitable
solubility
soluble
water: soluble
NCBI accession no.
UniProt accession no.
shipped in
dry ice
storage temp.
−70°C
Gene Information
human ... PDGFRB(5159)
Biochem/physiol Actions
The PDGFβ receptor is involved in the development of the kidney, heart, placenta, blood vessels, and cardiovascular system. It also helps to regulate interstitial fluid pressure in tissues thus preventing edema. The activation of the PDGFβ receptor plays a crucial role in the process of wound healing. In addition to these functions, its overexpression is related to gastric cancer.
Application
Useful for the study of enzyme kinetics, screening inhibitors, and selectivity profiling.
General description
Research area: Cell Cycle
Human PDGFRbeta (GenBank Accession No. NM_002609), cytoplasmic domain, amino acids 558-1106 (end) with N-terminal His-tag, MW= 62 kDa, expressed in Sf9 cells via a Baculovirus expression system.
Platelet-derived growth factor receptor (PDGFR) belongs to subclass III of receptor tyrosine kinases. The PDGFR exists as two isoforms, PDGFa and PDGFb-receptors, consisting of five extracellular immunoglobulin (Ig) loops and an intracellular tyrosine kinase (TK) domain.
Human PDGFRbeta (GenBank Accession No. NM_002609), cytoplasmic domain, amino acids 558-1106 (end) with N-terminal His-tag, MW= 62 kDa, expressed in Sf9 cells via a Baculovirus expression system.
Platelet-derived growth factor receptor (PDGFR) belongs to subclass III of receptor tyrosine kinases. The PDGFR exists as two isoforms, PDGFa and PDGFb-receptors, consisting of five extracellular immunoglobulin (Ig) loops and an intracellular tyrosine kinase (TK) domain.
signalword
Danger
hcodes
Hazard Classifications
Eye Irrit. 2 - Repr. 1B - Skin Irrit. 2
存储类别
6.1C - Combustible acute toxic Cat.3 / toxic compounds or compounds which causing chronic effects
wgk
WGK 1
flash_point_f
Not applicable
flash_point_c
Not applicable
法规信息
新产品
此项目有
The PDGF family: four gene products form five dimeric isoforms
Fredriksson, Linda and Li, Hong and Eriksson, Ulf
Cytokine & Growth Factor Reviews, 15(4) (2004)
Drug targeting to myofibroblasts: Implications for fibrosis and cancer
Yazdani S, et al.
Advanced Drug Delivery Reviews, 121, 101-116 (2017)
PDGFRB is a potential prognostic biomarker and correlated with immune infiltrates in gastric cancer
Liu B, et al.
Cancer Biomarkers : Section A of Disease Markers, 34(2), 251-264 (2022)
C H Heldin et al.
Physiological reviews, 79(4), 1283-1316 (1999-10-03)
Platelet-derived growth factor (PDGF) is a major mitogen for connective tissue cells and certain other cell types. It is a dimeric molecule consisting of disulfide-bonded, structurally similar A- and B-polypeptide chains, which combine to homo- and heterodimers. The PDGF isoforms
L Claesson-Welsh et al.
Molecular and cellular biology, 8(8), 3476-3486 (1988-08-01)
The structure of the human receptor for platelet-derived growth factor (PDGF) has been deduced through cDNA cloning. A 5.45-kilobase-pair cDNA clone predicts a 1,106-amino-acid polypeptide, including the cleavable signal sequence. The overall amino acid sequence similarity with the murine PDGF
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