推荐产品
生物来源
human
重组
expressed in E. coli
检测方案
≥60% (SDS-PAGE)
形式
aqueous solution
分子量
87.2 kDa
包装
pkg of 100 μg
储存条件
avoid repeated freeze/thaw cycles
NCBI登记号
UniProt登记号
运输
dry ice
储存温度
−70°C
基因信息
human ... SIRT1(23411)
一般描述
Human Sirtuin 1, GenBank Accession No. NM_012238), amino acids 193-741 with N-terminal ST tag, MW = 87.2 kDa, expressed in E. coli expression system.
应用
Useful for the study of enzyme kinetics, screening inhibitors, and selectivity profiling.
单位定义
One unit is defined as the amount of enzyme required to deacetylate 1 pmol of substrate/min at 37°C.
外形
Formulated in 25 mM Tris-HCl, pH 8.0, 100 mM NaCl, 0.05% Tween-20 and 20% glycerol.
制备说明
Thaw on ice. Upon first thaw, briefly spin tube containing enzyme to recover full content of the tube. Aliquot enzyme into single use aliquots. Store remaining undiluted enzyme in aliquots at -70°C. Note: Enzyme is very sensitive to freeze/thaw cycles.
WGK
WGK 1
闪点(°F)
Not applicable
闪点(°C)
Not applicable
法规信息
新产品
SIRT 1 Overexpression is Associated with Metastasis of Pancreatic Ductal Adenocarcinoma (PDAC) and Promotes Migration and Growth of PDAC Cells.
Li S, et al.
Medical Science Monitor : International Medical Journal of Experimental and Clinical Research, 22, 1593-1600 (2016)
[SIRT1].
Hattori Y and Ihara M.
Nihon Rinsho. Japanese Journal of Clinical Medicine, 74(4), 589-594 (2016)
Wen-Li Mu et al.
Stem cells (Dayton, Ohio), 33(7), 2135-2147 (2015-05-06)
Mouse somatic cells can be reprogrammed into induced pluripotent stem cells by defined factors known to regulate pluripotency, including Oct4, Sox2, Klf4, and c-Myc. Together with Oct4, Sox2 plays a major role as a master endogenous pluripotent genes trigger in
Yanxiang Li et al.
The Journal of nutritional biochemistry, 26(11), 1338-1347 (2015-08-25)
Nicotinic acid (NA) has recently been shown to inhibit inflammatory response in cardiovascular disease. Sirtuin1 (SIRT1), a NAD(+)-dependent class III histone deacetylase, participates in the regulation of cellular inflammation. We hypothesized that dietary supplementation of NA could attenuate vascular inflammation
Yun H Kim et al.
Vascular pharmacology, 72, 35-42 (2015-05-15)
Silent mating type information regulation 2 homolog 1 (SIRT1) is known as a key regulator in the protection of various vascular disorders, however, no direct evidences have been reported in the progression of atherosclerosis. Considering the pivotal role of matrix
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