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生物来源
human
质量水平
重组
expressed in insect cells
检测方案
≥90% (SDS-PAGE)
形式
lyophilized powder
效能
>0.004 units/mg
比活
≥40 units/μg
包装
pkg of 5 μg
UniProt登记号
运输
wet ice
储存温度
−70°C
基因信息
human ... GZMB(3002)
一般描述
Granzyme B (GzmB) is a serine protease which is stored in granules of activated cytotoxic T cells and NK cells. GZMB codes for granzyme B.
生化/生理作用
Granzyme B is considered as the marker of activated CTLs (cytotoxic T-cells), which mediates target-cell apoptosis. It induces apoptosis in caspase-dependent and caspase-independent manner. After contact with target cells, granzyme B is directionally exocytosed, and then enters the target cell with assistance from perforin. Granzyme B specifically cleaves after Asp residues, and particularly processes and activates various pro-caspases. This induces apoptosis in the target cell.
单位定义
One unit is defined as the amount of enzyme that hydrolyzes 1 pmol/min of IETD-AFC per min at 37°C in 50 mM HEPES, pH 7.5 containing 10 mM CaCl2.
外形
Lyophilized powder, containing HEPES buffer (original solution at pH 7.5)
WGK
WGK 3
闪点(°F)
Not applicable
闪点(°C)
Not applicable
法规信息
常规特殊物品
Granzyme B enters the mitochondria in a Sam50-, Tim22-and mtHsp70-dependent manner to induce apoptosis
Chiusolo V, et al.
Cell Death and Differentiation, 24(4), 747-747 (2017)
Risk of generalized vitiligo is associated with the common 55R-94A-247H variant haplotype of GZMB (encoding granzyme B).
Ferrara TM, et al.
The Journal of Investigative Dermatology, 133(6), 1677-1677 (2013)
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