SRE0001
胃蛋白酶 来源于猪胃粘膜
Suitable for manufacturing of diagnostic kits and reagents, lyophilized powder, ≥3200 units/mg protein
别名:
胃液素 来源于猪胃, 胃蛋白酶 A
质量水平
表单
lyophilized powder
比活
≥3200 units/mg protein
分子量
35 kDa
杂质
salt, essentially free
颜色
white to off-white
UniProt登记号
应用
diagnostic assay manufacturing
运输
wet ice
储存温度
−20°C
基因信息
pig ... LOC396892(396892)
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应用
胃蛋白酶切割可用于产生抗体的F(ab′)2 片段。有关胃蛋白酶的更多信息，请访问 www.sigma-aldrich.com/enzymeexplorer。
生化/生理作用
优先裂解：P1 和 P1′ 位的疏水性和芳族残基。降解胰岛素 β 链中的 Phe-Val、Gln-His、Glu-Ala、Ala-Leu、Leu-Tyr、Tyr-Leu、Gly-Phe、Phe-Phe 和 Phe-Tyr 键
分析说明
E1%/280法测定蛋白
最适pH值为2-4。在4 M尿素和3 M盐酸胍中可保持活性。在60°C时稳定。胃蛋白酶在pH 8.0-8.5下发生不可逆灭活。
其他说明
一个单位将在 37°C、pH2.0 下每分钟产生 ΔA 280 0.001，以 TCA 可溶产物计，以血红蛋白为底物。（最终体积 = 16 mL。）
查看有关 胃蛋白酶 的更多信息，请访问 www.sigma-aldrich.com/enzymeexplorer。
警示用语：
Danger
危险分类
Eye Irrit. 2 - Resp. Sens. 1 - Skin Irrit. 2 - STOT SE 3
靶器官
Respiratory system
储存分类代码
11 - Combustible Solids
WGK
WGK 1
闪点(°F)
Not applicable
闪点(°C)
Not applicable
法规信息
低风险生物材料
此项目有
Yi Sun et al.
Journal of natural products, 77(7), 1749-1752 (2014-06-25)
Two linear peptides, ahpatinin Ac (1) and ahpatinin Pr (2), were isolated together with the known ahpatinin (i)Bu, pepstatin Ac, pepstatin Pr, and pepsinostreptin from a Streptomyces sp. derived from a deep-sea sediment. The structure of ahpatinin Pr (2) was
Tina L Samuels et al.
The Annals of otology, rhinology, and laryngology, 119(3), 203-208 (2010-04-16)
Diagnosis of extraesophageal reflux (EER) currently relies on tools designed for diagnosis of gastroesophageal reflux. Such tools lack the sensitivity and reproducibility to detect the less frequent and mildly acidic reflux associated with upper airway disease. Pepsin has been posited
Adrian Allen et al.
American journal of physiology. Cell physiology, 288(1), C1-19 (2004-12-14)
Secretion of bicarbonate into the adherent layer of mucus gel creates a pH gradient with a near-neutral pH at the epithelial surfaces in stomach and duodenum, providing the first line of mucosal protection against luminal acid. The continuous adherent mucus
Michal Ciolkowski et al.
Biochimica et biophysica acta, 1834(10), 1982-1987 (2013-07-16)
In this study the ability of three polyamidoamine (PAMAM) dendrimers with different surface charge (positive, neutral and negative) to interact with a negatively charged protein (porcine pepsin) was examined. It was shown that the dendrimer with a positively charged surface
Christopher S Davis et al.
The Journal of surgical research, 185(2), e101-e108 (2013-07-13)
Aspiration of gastroesophageal refluxate has been implicated in the pathogenesis of idiopathic pulmonary fibrosis (IPF) and the progression of bronchiolitis obliterans syndrome after lung transplantation. The goals of the present study were to identify lung transplant patients at the greatest
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