SML1552
Tipiracil hydrochloride
≥98% (HPLC), thymidine phosphorylase inhibitor, powder
别名:
5-Chloro-6-[(2-imino-1-pyrrolidinyl)methyl]-2,4(1H,3H)-pyrimidinedione hydrochloride, TPI hydrochloride
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经验公式（希尔记法）:
C9H11ClN4O2 · HCl
化学文摘社编号:
分子量:
279.12
UNSPSC Code:
12352200
PubChem Substance ID:
NACRES:
NA.77
MDL number:
产品名称
Tipiracil hydrochloride, ≥98% (HPLC)
SMILES string
[H]Cl.ClC1=C(CN2C(CCC2)=N)NC(NC1=O)=O
InChI key
KGHYQYACJRXCAT-UHFFFAOYSA-N
InChI
1S/C9H11ClN4O2.ClH/c10-7-5(12-9(16)13-8(7)15)4-14-3-1-2-6(14)11;/h11H,1-4H2,(H2,12,13,15,16);1H
assay
≥98% (HPLC)
form
powder
storage condition
desiccated
color
white to beige
solubility
H2O: 5 mg/mL, clear (warmed)
storage temp.
2-8°C
Quality Level
Gene Information
human ... TYMP(1890)
Biochem/physiol Actions
Tipiracil is an inhibitor of thymidine phosphorylase.
Tipiracil is an inhibitor of thymidine phosphorylase. Tipiracil is used in combination with trifluridine as TAS-102 for the treatment of refractory metastatic colorectal cancer. Tipiracil increases the bioavailability of trifluridine by blocking the enzyme that would otherwise protect the tumors by metabolizing trifluridine.
存储类别
11 - Combustible Solids
wgk
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
法规信息
新产品
此项目有
Kei Higashikawa et al.
Nuclear medicine and biology, 82-83, 25-32 (2019-12-24)
Although liver biopsy is the gold standard for the diagnosis of nonalcoholic steatohepatitis (NASH), it has several problems including high invasiveness and sampling errors. Therefore, the development of alternative methods to overcome these disadvantages is strongly required. In this study
Sumaira Javaid et al.
PloS one, 14(11), e0225056-e0225056 (2019-11-20)
Natural flora is the richest source of novel therapeutic agents due to their immense chemical diversity and novel biological properties. In this regard, eighteen natural products belonging to different chemical classes were evaluated for their thymidine phosphorylase (TP) inhibitory activity.
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