质量水平
检测方案
≥98% (HPLC)
形式
powder
颜色
white to beige
溶解性
DMSO: 20 mg/mL, clear
储存温度
2-8°C
SMILES字符串
N=C(NCCCCC)N/N=C/C1=CNC2=C1C=C(OC)C=C2.OC(/C=C\C(O)=O)=O
InChI
1S/C16H23N5O.C4H4O4/c1-3-4-5-8-18-16(17)21-20-11-12-10-19-15-7-6-13(22-2)9-14(12)15;5-3(6)1-2-4(7)8/h6-7,9-11,19H,3-5,8H2,1-2H3,(H3,17,18,21);1-2H,(H,5,6)(H,7,8)/b20-11+;2-1-
InChI key
CPDDZSSEAVLMRY-FEQFWAPWSA-N
基因信息
human ... HTR4(3360)
应用
Tegaserod maleate has been used to study its cytotoxic effects on human astrocytes and to study its effects as an anti-glioblastoma agent.
生化/生理作用
It stimulates neurotransmitter release from enteric nerves and regularizes gastrointestinal function. Tegaserod has been used to treat irritable bowel syndrome associated with constipation and chronic constipation.
Tegaserod is a potent full agonist at serotonin 5-HT4 receptors with an EC50 of 7 nM.
储存分类代码
11 - Combustible Solids
WGK
WGK 3
闪点(°F)
Not applicable
闪点(°C)
Not applicable
Corrado Blandizzi and Carmelo Scarpignato
Side Effects of Drugs Annual: A world-wide yearly survey of new data and trends in adverse drug reactions., 33, 741-767 (2011)
Screening of clinically-applicable drugs in patient-derived glioblastoma stem-like cells identifies amiodarone, clofazimine and triptolide as potential anti-glioma agents
Sigrid S
Combinatorial Chemistry: From Theory to Application (2015)
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