质量水平
检测方案
≥98% (HPLC)
形式
powder
旋光性
[α]/D +18 to +24°, c = 1 in chloroform-d
颜色
white to beige
溶解性
DMSO: 2 mg/mL, clear
储存温度
−20°C
SMILES字符串
O=C1C=C[C@@]2(C)[C@](CC[C@]3([H])[C@]2([H])CC[C@@]4(C)[C@@]3([H])CC[C@@H]4C(NC5=CC(C(F)(F)F)=CC=C5C(F)(F)F)=O)([H])N1
InChI
1S/C27H30F6N2O2/c1-24-11-9-17-15(4-8-21-25(17,2)12-10-22(36)35-21)16(24)6-7-19(24)23(37)34-20-13-14(26(28,29)30)3-5-18(20)27(31,32)33/h3,5,10,12-13,15-17,19,21H,4,6-9,11H2,1-2H3,(H,34,37)(H,35,36)/t15-,16-,17-,19+,21+,24-,25+/m0/s1
InChI key
JWJOTENAMICLJG-QWBYCMEYSA-N
基因信息
human ... SRD5A1(6715) , SRD5A2(6716) , SRD5A3(79644)
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生化/生理作用
度他雄胺是1型和2型5α-还原酶同工酶的有效双重抑制剂 (IC50 = 6 nM 5-AR1; 7 nM 5-AR2)。度他雄胺可阻断睾丸激素向二氢睾丸酮的转化,并在临床上用于治疗良性前列腺增生 (BPH)。
警示用语:
Danger
危险声明
危险分类
Carc. 2 - Repr. 1B
WGK
WGK 3
闪点(°F)
Not applicable
闪点(°C)
Not applicable
法规信息
新产品
Urology, 85(1), 274-274 (2014-12-03)
To evaluate histologic change in human prostate samples treated with dutasteride and to elucidate direct effects of dutasteride on human prostate tissue, the present study was conducted by using a xenograft model with improved severe combined immunodeficient (super-SCID) mice, although
Expert opinion on pharmacotherapy, 14(10), 1399-1408 (2013-06-12)
Benign prostatic hyperplasia (BPH) is an age-related phenomenon associated with prostatic enlargement and bladder outlet obstruction that can cause significant lower urinary tract symptoms that greatly affect quality of life. Dutasteride is a selective inhibitor of type 1 and type
Arthritis research & therapy, 22(1), 121-121 (2020-05-26)
Ankylosing spondylitis (AS) is characteristically male-predominant, and progressive spinal ankylosis affects male patients more severely; however, the hormonal effects in males with AS are poorly understood. In the present study, the regulatory effects of dutasteride, a 5-α reductase inhibitor that
5α-Reductase Inhibition Coupled with Short Off Cycles Increases Survival in the LNCaP Xenograft Prostate Tumor Model on Intermittent Androgen Deprivation Therapy.
The Journal of Urology, Oct 31 (2014)
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