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Merck
CN

SML1221

Sigma-Aldrich

度他雄胺

≥98% (HPLC)

别名:

17β-N-[2,5-双(三氟甲基)苯基]-氨基甲酰基-4-氮杂-5α-雄烷-1-烯-3-酮, (5α,17β)-N-[2,5-双(三氟甲基)苯基] -3-氧代-4-氮杂杂芳-1-烯-17-羧酰胺

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About This Item

经验公式(希尔记法):
C27H30F6N2O2
分子量:
528.53
MDL编号:
UNSPSC代码:
51111800
PubChem化学物质编号:
NACRES:
NA.77

质量水平

检测方案

≥98% (HPLC)

形式

powder

旋光性

[α]/D +18 to +24°, c = 1 in chloroform-d

颜色

white to beige

溶解性

DMSO: 2 mg/mL, clear

储存温度

−20°C

SMILES字符串

O=C1C=C[C@@]2(C)[C@](CC[C@]3([H])[C@]2([H])CC[C@@]4(C)[C@@]3([H])CC[C@@H]4C(NC5=CC(C(F)(F)F)=CC=C5C(F)(F)F)=O)([H])N1

InChI

1S/C27H30F6N2O2/c1-24-11-9-17-15(4-8-21-25(17,2)12-10-22(36)35-21)16(24)6-7-19(24)23(37)34-20-13-14(26(28,29)30)3-5-18(20)27(31,32)33/h3,5,10,12-13,15-17,19,21H,4,6-9,11H2,1-2H3,(H,34,37)(H,35,36)/t15-,16-,17-,19+,21+,24-,25+/m0/s1

InChI key

JWJOTENAMICLJG-QWBYCMEYSA-N

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生化/生理作用

度他雄胺是1型和2型5α-还原酶同工酶的有效双重抑制剂 (IC50 = 6 nM 5-AR1; 7 nM 5-AR2)。度他雄胺可阻断睾丸激素向二氢睾丸酮的转化,并在临床上用于治疗良性前列腺增生 (BPH)。

象形图

Health hazard

警示用语:

Danger

危险声明

危险分类

Carc. 2 - Repr. 1B

WGK

WGK 3

闪点(°F)

Not applicable

闪点(°C)

Not applicable

法规信息

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