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SML1175

罗咪酯肽

Name: 罗咪酯肽
Brand: SIGMA

≥98% (HPLC), powder, histone deacetylase inhibitor

别名:

FK228, FR901228, L-缬氨酸, N-((3S,4E)-3-羟基-7-巯基-1-氧代-4-庚基)-D-戊基-D-半胱氨酸-(2Z)-2-氨基-2-丁烯氧基-, (4-1)-内酯,环状(1-2)-二硫化物, 环[(2Z)-2-氨基-2-丁烯酰基-L-戊基-(3S,4E)-3-羟基-7-巯基-4-庚烯酰基-D-戊基-D-半胱氨酰]环状(35)-二硫化物, 缩酚酸肽

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经验公式（希尔记法）:

C₂₄H₃₆N₄O₆S₂

化学文摘社编号:

128517-07-7

分子量:

540.70

UNSPSC Code:

12352200

PubChem Substance ID:

329825701

NACRES:

NA.77

MDL number:

MFCD18433404

Assay:

≥98% (HPLC)

Form:

powder

Quality level:

100

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属性

产品名称

罗咪酯肽, ≥98% (HPLC)

Quality Level

100

assay

≥98% (HPLC)

form

powder

color

white to beige

solubility

DMSO: 25 mg/mL, clear

storage temp.

−20°C

SMILES string

O=C(N/C(C(N[C@@H](C(C)C)C(O[C@@]1([H])CC2=O)=O)=O)=C\C)[C@@H](CSSCC/C=C/1)NC([C@H](N2)C(C)C)=O

InChI

1S/C24H36N4O6S2/c1-6-16-21(30)28-20(14(4)5)24(33)34-15-9-7-8-10-35-36-12-17(22(31)25-16)26-23(32)19(13(2)3)27-18(29)11-15/h6-7,9,13-15,17,19-20H,8,10-12H2,1-5H3,(H,25,31)(H,26,32)(H,27,29)(H,28,30)/b9-7+,16-6-/t15-,17-,19-,20+/m1/s1

InChI key

OHRURASPPZQGQM-GCCNXGTGSA-N

Gene Information

human ... HDAC1(3065), HDAC10(83933), HDAC11(79885), HDAC2(3066), HDAC3(8841), HDAC4(9759), HDAC5(10014), HDAC6(10013), HDAC7(51564), HDAC8(55869), HDAC9(9734)

说明

Biochem/physiol Actions

罗米地辛可促进细胞凋亡，同时阻碍神经胶质瘤模型中肿瘤的生长。

罗米地辛是HDAC1和HDAC2的一种非常有效的天然前药抑制剂，可被谷胱甘肽转化为活性形式。罗米地辛对HDAC1和HDAC2的IC₅₀ 值分别为36 nM和47 nM。它可杀死过表达Bcl-2和Bcl-XL的淋巴瘤细胞系，并已被批准用于治疗皮肤T细胞淋巴瘤（CTCL）和外周T细胞淋巴瘤，以及多种其他癌症。

罗米地辛是HDAC1和HDAC2的非常有效的天然前药抑制剂；抗肿瘤药。

存储类别

11 - Combustible Solids

wgk

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

历史批次信息供参考:

分析证书(COA)

Lot/Batch Number

0000209809

0000178117

0000173871

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SCCOHT tumors acquire chemoresistance and protection by interacting mesenchymal stroma/stem cells within the tumor microenvironment.

Anna Otte et al.

International journal of oncology, 49(6), 2453-2463 (2016-10-18)

Chemotherapeutic drug testing of SCCOHT-1 and BIN-67 tumor cells revealed synergistic growth-inhibition of >95% in vitro with a combination of foretinib and FK228. Application of this drug combination in vivo in NODscid mice-induced SCCOHT-1GFP tumors was associated with ~6-fold reduction in

Romidepsin Promotes Osteogenic and Adipocytic Differentiation of Human Mesenchymal Stem Cells through Inhibition of Histondeacetylase Activity.

Dalia Ali et al.

Stem cells international, 2018, 2379546-2379546 (2018-05-08)

Bone marrow mesenchymal stem cells (BMSCs) are adult multipotent stem cells that can differentiate into mesodermal lineage cells, including adipocytes and osteoblasts. However, the epigenetic mechanisms governing the lineage-specific commitment of BMSCs into adipocytes or osteoblasts are under investigation. Herein

Characterization of the HIV-1 transcription profile after romidepsin administration in ART-suppressed individuals.

Sara Moron-Lopez et al.

AIDS (London, England), 33(3), 425-431 (2018-12-12)

Reversing HIV-1 latency has been suggested as a strategy to eradicate HIV-1. We investigated the effect of romidepsin on the HIV transcription profile in participants from the REDUC part B clinical trial. Seventeen participants on suppressive antiretroviral therapy were vaccinated

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货号	GTIN
SML1175-1MG	04061826274460