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Merck
CN

SML1070

SR-58611A

≥98% (HPLC)

别名:

Amibegron, [[(7S)-7-[[(2R)-2-(3-Chlorophenyl)-2-hydroxyethyl]amino]-5,6,7,8-tetrahydro-2-naphthalenyl]oxy acetic acid ethyl ester hydrochloride

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关于此项目

经验公式（希尔记法）:
C22H26ClNO4 · HCl
化学文摘社编号:
121524-09-2
分子量:
440.36
NACRES:
NA.77
PubChem Substance ID:
329825649
UNSPSC Code:
12352200
MDL number:
MFCD00886563

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产品名称

SR-58611A, ≥98% (HPLC)

InChI

1S/C22H26ClNO4.ClH/c1-2-27-22(26)14-28-20-9-7-15-6-8-19(11-17(15)12-20)24-13-21(25)16-4-3-5-18(23)10-16;/h3-5,7,9-10,12,19,21,24-25H,2,6,8,11,13-14H2,1H3;1H/t19-,21-;/m0./s1

SMILES string

ClC1=CC([C@@H](O)CN[C@@H]2CC(C=C(OCC(OCC)=O)C=C3)=C3CC2)=CC=C1.Cl

InChI key

NQIZCDQCNYCVAS-RQBPZYBGSA-N

assay

≥98% (HPLC)

form

powder

optical activity

[α]/D -75 to -95°, c = 0.5 in methanol

color

white to beige

solubility

DMSO: 20 mg/mL, clear

storage temp.

−20°C

Quality Level

100

Gene Information

human ... ADRB3(155)

相关类别

Biochem/physiol Actions

SR58611A is a potent, specific 3β adrenergic receptor agonist.
SR58611A is a potent, specific b3 adrenergic receptor agonist. The EC50 for reduction of β3-mediated spontaneous motility in rat distal colon sections is 3.5 nM. Minimal anti-depressant efficacious doses for SR58611A are 0.1-0.3 mpk in rodent models.

Features and Benefits

This compound is a featured product for Neuroscience research. Click here to discover more featured Neuroscience products. Learn more about bioactive small molecules for other areas of research at sigma.com/discover-bsm.

pictograms

Environment
GHS09

signalword

Warning

hcodes

H410

Hazard Classifications

Aquatic Acute 1 - Aquatic Chronic 1

存储类别

11 - Combustible Solids

wgk

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

历史批次信息供参考:

分析证书(COA)

Lot/Batch Number
0000483778
0000483778
0000481130
0000481130
0000096672

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Zili Wang et al.
Journal of shoulder and elbow surgery, 30(2), 373-386 (2020-07-01)
Rotator cuff (RC) muscle atrophy and fatty infiltration (FI) are independent factors correlated with failure of attempted tendon repair in larger RC tears. However, there is no effective treatment for RC muscle atrophy and FI at this time. The recent

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DISCOVER Bioactive Small Molecules for Neuroscience

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