推荐产品
质量水平
方案
≥98% (HPLC)
表单
powder
颜色
white to beige
溶解性
DMSO: 10 mg/mL at warmed, clear
运输
wet ice
储存温度
−20°C
SMILES字符串
CC(C)c1ccc2Oc3nc(N)c(cc3C(=O)c2c1)C(O)=O
InChI
1S/C16H14N2O4/c1-7(2)8-3-4-12-9(5-8)13(19)10-6-11(16(20)21)14(17)18-15(10)22-12/h3-7H,1-2H3,(H2,17,18)(H,20,21)
InChI key
SGRYPYWGNKJSDL-UHFFFAOYSA-N
基因信息
human ... PDE4A(5141) , PDE4B(5142) , PDE4C(5143) , PDE4D(5144)
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一般描述
Amlexanox is an anti-allergic drug with anti-inflammatory properties.
生化/生理作用
Amlexanox elevates the amount of nonsense-containing mRNAs in treated cells and helps to generate full-length proteins effectively.
Amlexanox is an anti-allergy and anti-asthma drug that blocks histamine and leukotriene release from leukocytes and mast cells. Amlexanox has also been shown to inhibit cahaperone activity of Hsp90, and S100A13, which is involved in transport of proteins devoid of signal peptide sequences.
Amlexanox is an anti-allergy, anti-ulcer drug; S100A13 inhibitor.
警示用语：
Warning
危险声明
危险分类
Acute Tox. 4 Oral
储存分类代码
11 - Combustible Solids
WGK
WGK 3
闪点(°F)
Not applicable
闪点(°C)
Not applicable
法规信息
新产品
历史批次信息供参考:
分析证书(COA)
Lot/Batch Number
Nesrine Benslimane et al.
Pharmaceuticals (Basel, Switzerland), 16(7) (2023-07-29)
Nonsense mutations are involved in multiple peripheral neuropathies. These mutations induce the presence of a premature termination codon (PTC) at the mRNA level. As a result, a dysfunctional or truncated protein is synthesized, or even absent linked to nonsense-mediated mRNA
Brenda Murray et al.
Journal of oral pathology & medicine : official publication of the International Association of Oral Pathologists and the American Academy of Oral Pathology, 34(7), 413-419 (2005-07-14)
Recurrent minor aphthous ulceration (RAU) is a common condition which is multifactorial in origin. This study, firstly, aimed to treat the prodromal stage of RAU with Aphtheal (5% amlexanox paste) to determine if ulcer development could be prevented. A second
Sandhya G Rani et al.
Biochemistry, 49(11), 2585-2592 (2010-02-25)
S100A13 and acidic fibroblast growth factor (FGF1) are involved in a wide array of important biological processes, such as angiogenesis, cell differentiation, neurogenesis, and tumor growth. Generally, the biological function of FGF1 is to recognize a specific tyrosine kinase on
R W Barrons
American journal of health-system pharmacy : AJHP : official journal of the American Society of Health-System Pharmacists, 58(1), 41-50 (2001-02-24)
The clinical features, etiology, and treatment of recurrent aphthous ulcers (RAU) are discussed. Aphthous ulcers are among the most common oral lesions in the general population, with a frequency of up to 25% and three-month recurrence rates as high as
Dakshinamurthy Rajalingam et al.
Biochemistry, 44(47), 15472-15479 (2005-11-23)
Fibroblast growth factor (FGF-1) lacks a signal sequence and is exported by an unconventional release mechanism. The nonclassical export of FGF-1 has been shown to be inhibited by an anti-allergic and anti-inflammatory drug, amlexanox (AMX). We investigate the molecular mechanism(s)
商品
Bioactive small molecules for immune system signaling target identification/validation and antibiotics, antivirals, and antifungals offered.
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