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质量水平
方案
≥95% (HPLC)
表单
powder
旋光性
[α]/D +70 to +80°, c = 1 in H2O
储存条件
desiccated
颜色
white to beige
溶解性
H2O: 10 mg/mL, clear
运输
wet ice
储存温度
−20°C
SMILES字符串
OC[C@H]1O[C@H](C[C@@H]1O)n2cnc3[C@H](O)CN=CNc23
InChI
1S/C11H16N4O4/c16-3-8-6(17)1-9(19-8)15-5-14-10-7(18)2-12-4-13-11(10)15/h4-9,16-18H,1-3H2,(H,12,13)/t6-,7+,8+,9+/m0/s1
InChI key
FPVKHBSQESCIEP-JQCXWYLXSA-N
基因信息
human ... ADA(100)
应用
Pentostatin has been used in in vivo anti-tumor studies. It has also been used along with cyclophosphamide as a selective B-cell immune suppression regimen to explore solid tumor therapy by selectively targeting stromal endothelial cells.
生化/生理作用
Pentostatin is a ring-expanded nucleoside (REN) that potently inhibits adenosine deaminase, which leads to lymphocyte toxicity. Pentostatin is used as anticancer agent to treat leukemia (hairy cell leukemia and chronic lymphocytic leukemia) and is investigated as an agent to treat graft-versus-host disease (GVHD).
Pentostatin is an immunosuppressant; adenosine deaminase inhibitor; ring-expanded nucleoside (REN).
Pentostatin/2′-deoxycoformycin is used to treat patients with Waldenström′s macroglobulinemia.
特点和优势
This compound is featured on the Adenosine Receptors page of the Handbook of Receptor Classification and Signal Transduction. To browse other handbook pages, click here.
其他说明
Air sensitve; hygroscopic.
警示用语：
Danger
危险声明
危险分类
Acute Tox. 3 Oral
储存分类代码
6.1C - Combustible acute toxic Cat.3 / toxic compounds or compounds which causing chronic effects
WGK
WGK 3
闪点(°F)
Not applicable
闪点(°C)
Not applicable
法规信息
新产品
历史批次信息供参考:
分析证书(COA)
Lot/Batch Number
Da-Tong Ju et al.
Nutrients, 11(7) (2019-07-25)
Vasicinone is a quinazoline alkaloid isolated from the Adhatoda vasica plant. In this study, we explored the neuroprotective effect and underlying molecular mechanism of vasicinone against paraquat-induced cellular apoptosis in SH-SY5Y cells. Vasicinone reduced the paraquat-induced loss of cell viability
Behrouz Elahi et al.
Colloids and surfaces. B, Biointerfaces, 181, 830-836 (2019-06-30)
Bio-based synthesis of Nano-Ceria (NC) was performed in Linum usitatissimum L. (Lu) seeds extract as capping agent. Obtained gel was calcined at 400, 500, and 600 °C to investigate the effect of temperature on the size and morphology of the particles.
Pentostatin, cyclophosphamide and rituximab is a safe and effective treatment in patients with Waldenstrom?s macroglobulinemia
Herth I, et al.
Leukemia Lymphoma, 56(1), 97-102 (2015)
Hairy-cell leukemia: induction of complete remission with pentostatin (2'-deoxycoformycin).
Spiers AS, et al.
Journal of clinical oncology : official journal of the American Society of Clinical Oncology, 2(12), 1336-1342 (1984)
Solid tumor therapy by selectively targeting stromal endothelial cells
Liu S, et al.
Proceedings of the National Academy of Sciences of the USA, 113(28), E4079-E4087 (2016)
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