所有图片(1)
别名:
(4S,6S)-4H-Thieno[2,3-b]thiopyran-2-sulfonamide, 4-(ethylamino)-5,6-dihydro-6-methyl-, 7,7-dioxide, 4S,6S-Dorzolamide, L-671,152, MK-507
经验公式（希尔记法）:
C10H16N2O4S3
推荐产品
质量水平
检测方案
≥98% (HPLC)
形式
powder
旋光性
[α]/D -25 to -35°, c = 1 in methanol
颜色
white to beige
溶解性
DMSO: 5 mg/mL (clear solution, warmed)
储存温度
room temp
SMILES字符串
CCN[C@H]1C[C@H](C)S(=O)(=O)c2sc(cc12)S(N)(=O)=O
InChI
1S/C10H16N2O4S3/c1-3-12-8-4-6(2)18(13,14)10-7(8)5-9(17-10)19(11,15)16/h5-6,8,12H,3-4H2,1-2H3,(H2,11,15,16)/t6-,8-/m0/s1
InChI key
IAVUPMFITXYVAF-XPUUQOCRSA-N
基因信息
human ... CA2(760)
生化/生理作用
Dorzolamide is a potent carbonic anhydrase II inhibitor with an IC50 value of 0.16 nM on human erythrocyte carbonic anhydrase II in vitro. It has been found to lower increased intraocular pressure in open-angle glaucoma and ocular hypertension.
警示用语：
Warning
危险声明
危险分类
Acute Tox. 4 Oral
WGK
WGK 3
闪点(°F)
Not applicable
闪点(°C)
Not applicable
Mohammed Shadab Shahab et al.
International journal of biological macromolecules, 163, 2392-2404 (2020-09-27)
The present research work was designed to develop dorzolamide-loaded chitosan-coated polycaprolactone nanoparticles (DRZ-CS-PCL-NPs) for improved ocular delivery. The nanoparticles were prepared by single-step emulsification technique and optimized using the three-factor three-level Box-Behnken design. The optimized DRZ-CS-PCL-NPs prepared with the composition
Daniel Laroche et al.
Journal of glaucoma, 27(10), e158-e161 (2018-07-26)
We describe a novel technique comprising the use of trypan blue to confirm aqueous outflow to collector channels and aqueous veins after goniotomy with the Kahook Dual Blade (New World Medical, Rancho Cucamonga, CA). Intraocular dyes have been safely used
Un Chul Park et al.
Retina (Philadelphia, Pa.), 40(7), 1359-1366 (2019-06-06)
To evaluate the efficacy and safety of intravitreal dexamethasone (DEX) implant in retinitis pigmentosa patients with cystoid macular edema (CME). In this randomized, noncontrolled, paired-eye, single crossover clinical trial, one eye of retinitis pigmentosa patients with bilateral CME with central
John S Sapienza et al.
Veterinary ophthalmology, 22(4), 520-528 (2018-10-26)
The purpose of this study was to report the preliminary results of a novel micropulse transscleral diode laser cyclophotocoagulation (MP-TSCP) as primary therapy for glaucomatous dogs. Client owned dogs undergoing MP-TSCP therapy at a veterinary referral center. Retrospective study of
Riku P J Arvola et al.
Cornea, 35(4), 451-455 (2016-02-05)
Treating corneal neurotrophic ulcers is challenging. Topical application of matrix regeneration therapy (RGTA), which is a dextran derivative polymer and heparan sulfate analog, is a promising regenerative therapy and an alternative or additional therapeutic regimen when corneal healing is compromised.
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