跳转至内容
Merck
CN
所有图片(1)

文件

SML0184

Sigma-Aldrich

人参皂苷 Rg3

≥98% (HPLC)

登录查看公司和协议定价
所有图片(1)
别名:
(3β, 12β）-12,20-二羟基 dmar-24-烯-3-基 2- O -β- D -吡喃葡萄糖基-β- D -吡喃葡萄糖苷, 20 (S)-人参皂苷-Rg3, Rg3
经验公式（希尔记法）:
C42H72O13
CAS号:
14197-60-5
分子量:
785.01
MDL编号:
MFCD06410950
UNSPSC代码:
12352200
PubChem化学物质编号:
329825213
NACRES:
NA.77

质量水平

100

检测方案

≥98% (HPLC)

形式

powder

旋光性

[α]/D +10 to +20°, c = 1 in methanol

储存条件

desiccated

颜色

white to beige

溶解性

DMSO: ≥5 mg/mL

储存温度

2-8°C

SMILES字符串

C\C(C)=C\CC[C@](C)(O)[C@H]1CC[C@]2(C)[C@@H]1[C@H](O)C[C@@H]3[C@@]4(C)CC[C@H](O[C@@H]5O[C@H](CO)[C@@H](O)[C@H](O)[C@H]5O[C@@H]6O[C@H](CO)[C@@H](O)[C@H](O)[C@H]6O)C(C)(C)[C@@H]4CC[C@@]23C

InChI

1S/C42H72O13/c1-21(2)10-9-14-42(8,51)22-11-16-41(7)29(22)23(45)18-27-39(5)15-13-28(38(3,4)26(39)12-17-40(27,41)6)54-37-35(33(49)31(47)25(20-44)53-37)55-36-34(50)32(48)30(46)24(19-43)52-36/h10,22-37,43-51H,9,11-20H2,1-8H3/t22-,23+,24+,25+,26-,27+,28-,29-,30+,31+,32-,33-,34+,35+,36-,37-,39-,40+,41+,42-/m0/s1

InChI key

RWXIFXNRCLMQCD-JBVRGBGGSA-N

正在寻找类似产品? 访问 产品对比指南

应用

人参皂苷 Rg3 可能用于细胞信号传导研究。
人参皂苷 Rg3 用于研究其对长QT综合征（LQTS）2-人诱导多能干细胞（hiPSC-CM）中延迟整流钾电流（IKr）通道的调控作用。

生化/生理作用

人参皂苷 Rg3 是从 人参中分离得到的天然产物 。与其他人参皂甙相似，它具有心脏保护作用。人参皂甙 Rg3 通过与通道孔入口的相互作用增强心脏、hERG (IKr) 和 KCNQ (Iks) 通道电流。它还通过调节 p44/42 MAPK 活化抑制棕榈酸酯诱导的 MIN6N8 小鼠胰岛素瘤 β 细胞凋亡。人参皂苷 Rg3 提高转录因子 Nrf2 的级别，诱导多药耐药相关蛋白 (Mrp) 1 和 Mrp3 的 mRNA 水平。Rg3 通过减弱小胶质细胞对全身 LPS 处理的反应来调节神经炎症。它激活 HepG2 细胞中的 AMPK，减少脂质蓄积，从而降低血脂异常导致的心血管疾病风险。

特点和优势

该化合物在受体分类和信号转导手册的钾通道页面上有重点介绍。想要浏览手册的其他页面， 请单击此处。

象形图

Exclamation mark
GHS07

警示用语：

Warning

危险声明

H302

预防措施声明

P301 + P312 + P330

危险分类

Acute Tox. 4 Oral

WGK

WGK 1

闪点(°F)

Not applicable

闪点(°C)

Not applicable

分析证书(COA)

输入产品批号来搜索 分析证书(COA) 。批号可以在产品标签上"批“ （Lot或Batch）字后找到。

已有该产品？

在文件库中查找您最近购买产品的文档。

访问文档库

Seohyun Lee et al.
International journal of molecular sciences, 13(5), 5729-5739 (2012-07-04)
Cardiovascular disease (CVD) is one of the main causes of mortality worldwide, and dyslipidemia is a major risk factor for CVD. Ginseng has been widely used in the clinic to treat CVD. Ginsenoside Rg3, one of the major active components
Sang Il Gum et al.
Oxidative medicine and cellular longevity, 2013, 957947-957947 (2013-06-15)
Previously, we found that Korean red ginseng suppressed acetaminophen (APAP)-induced hepatotoxicity via alteration of its metabolic profile involving GSTA2 induction and that ginsenoside Rg3 was a major component of this gene induction. In the present study, therefore, we assessed the
Xiaojie Wei et al.
International immunology, 24(7), 465-471 (2012-03-20)
Our previous investigation demonstrated that ginsenoside Rg3 was active in promotion of the immune response. In this study, two epimers, 20(R)-Rg3 and 20(S)-Rg3, were compared for their adjuvant effects on the immune response against ovalbumin (OVA). BALB/c mice were immunized
Sun-Min Park et al.
Biological & pharmaceutical bulletin, 35(9), 1546-1552 (2012-09-15)
Neuroinflammation, characterized by activation of microglia and expression of major inflammatory mediators, contributes to neuronal damage in addition to acute and chronic central nervous system (CNS) disease progression. The present study investigated the immune modulatory effects of ginsenoside Rg3, a
Jian-Wen Jiang et al.
World journal of gastroenterology, 17(31), 3605-3613 (2011-10-12)
To investigate the anti-tumor function of ginsenoside Rg3 on hepatocellular carcinoma (HCC) in vitro and in vivo, and its mechanism. Hep1-6 and HepG2 cells were treated by Rg3 in different concentrations (0, 50, 100 and 200 μg/mL) in vitro. After
查看所有相关文献

商品

Potassium Channels

We offer many products related to potassium channels for your research needs.

钾通道

我们可提供多种与钙通道相关的产品以满足您的各类研究需求。

我们的科学家团队拥有各种研究领域经验，包括生命科学、材料科学、化学合成、色谱、分析及许多其他领域.

联系技术服务部门