所有图片(1)
别名:
2,2′-(oxydimethanediyl)bis(5-nitro-1H-benzimidazole), 2,2′-(oxydimethanediyl)bis(6-nitro-1H-benzimidazole), 5-nitro-2-{[(6-nitro-1H-benzimidazol-2-yl)methoxy]methyl}-1H-benzimidazole
经验公式（希尔记法）:
C16H12N6O5
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质量水平
检测方案
≥98% (HPLC)
形式
powder
颜色
white to tan
溶解性
DMSO: ≥12 mg/mL
储存温度
2-8°C
SMILES字符串
[O-][N+](=O)c1ccc2nc(COCc3nc4ccc(cc4[nH]3)[N+]([O-])=O)[nH]c2c1
InChI
1S/C16H12N6O5/c23-21(24)9-1-3-11-13(5-9)19-15(17-11)7-27-8-16-18-12-4-2-10(22(25)26)6-14(12)20-16/h1-6H,7-8H2,(H,17,19)(H,18,20)
InChI key
ZQPXNYLXYNRFNP-UHFFFAOYSA-N
基因信息
human ... KCNJ1(3758)
应用
VU591 may be used in cell signaling studies.
生化/生理作用
VU591 is a Potassium Inwardly-Rectifying Channel (KCNJ1 or ROMK) specific inhibitor (IC50 = 240 nM) that is closely related to VU590. Unlike VU590, VU591 does not inhibit Kir7.1. The compound has a modest effect on Kir6.2/SUR1, causing 17% inhibition at 10 uM.
特点和优势
This compound is featured on the Potassium Channels page of the Handbook of Receptor Classification and Signal Transduction. To browse other handbook pages, click here.
WGK
WGK 3
闪点(°F)
Not applicable
闪点(°C)
Not applicable
Jiun-Lin Horng et al.
Scientific reports, 7(1), 16215-16215 (2017-11-28)
Molecular mechanisms of Na
Guglielmo Schiano et al.
Scientific reports, 9(1), 19517-19517 (2019-12-22)
Uromodulin, the most abundant protein in normal urine, is produced by cells lining the thick ascending limb (TAL) of the loop of Henle. Uromodulin regulates the activity of the potassium channel ROMK in TAL cells. Common variants in KCNJ1, the
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