SML0060
NB001
≥98% (HPLC)
别名:
5-[[2-（6-氨基-9H-嘌呤-9-基）乙基]氨基]戊-1-醇；HTS 09836
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选择尺寸
关于此项目
经验公式（希尔记法）:
C12H20N6O
化学文摘社编号:
分子量:
264.33
NACRES:
NA.77
PubChem Substance ID:
UNSPSC Code:
41106305
MDL number:
产品名称
NB001, ≥98% (HPLC)
InChI
1S/C12H20N6O/c13-11-10-12(16-8-15-11)18(9-17-10)6-5-14-4-2-1-3-7-19/h8-9,14,19H,1-7H2,(H2,13,15,16)
SMILES string
Nc1ncnc2n(CCNCCCCCO)cnc12
InChI key
CVPTTZZCRDVGSU-UHFFFAOYSA-N
assay
≥98% (HPLC)
form
powder
color
white to tan
solubility
H2O: ≥24 mg/mL
storage temp.
−20°C
Quality Level
Application
NB001可用于腺苷酸环化酶1 介导的细胞信号传导研究。
Biochem/physiol Actions
NB001，最初被认为是腺苷酸环化酶1（AC1）的选择性抑制剂，新证据表明 NB001 不直接与AC1 相互作用。NB001可通过依赖于AC1的未知机制减少细胞中cAMP的积累。
Features and Benefits
该化合物是环核苷酸研究的推荐产品。点击此处查看更多特色环核苷酸产品。在sigma.com/discover-bsm 上了解有关生物活性小分子在其他研究领域的更多信息。
signalword
Danger
hcodes
Hazard Classifications
Acute Tox. 3 Oral
存储类别
6.1C - Combustible acute toxic Cat.3 / toxic compounds or compounds which causing chronic effects
wgk
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
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Nature, 557(7705), 434-438 (2018-05-11)
The dense microbial ecosystem in the gut is intimately connected to numerous facets of human biology, and manipulation of the gut microbiota has broad implications for human health. In the absence of profound perturbation, the bacterial strains that reside within
Kelly E Bosse et al.
The Journal of pharmacology and experimental therapeutics, 363(2), 148-155 (2017-08-26)
Neuroadaptive responses to chronic ethanol, such as behavioral sensitization, are associated with
Sung-Chul Lim et al.
The Korean journal of physiology & pharmacology : official journal of the Korean Physiological Society and the Korean Society of Pharmacology, 21(4), 397-405 (2017-07-15)
MDL-12330A is a widely used adenylyl cyclase (AC) inhibitor that blocks AC/cAMP signaling. In this study, we demonstrated a novel antitumor activity of this drug in gastric carcinoma (GC) cell lines. In these GC cells, MDL-12330A reduced cell viability and
Ryan B Griggs et al.
Neurobiology of disease, 127, 76-86 (2019-02-27)
Painful diabetic neuropathy (PDN) is a devastating neurological complication of diabetes. Methylglyoxal (MG) is a reactive metabolite whose elevation in the plasma corresponds to PDN in patients and pain-like behavior in rodent models of type 1 and type 2 diabetes.
Shui-Bing Liu et al.
Journal of neurochemistry, 153(2), 252-263 (2019-10-31)
Cortical areas including the anterior cingulate cortex (ACC) play critical roles in different types of chronic pain. Most of previous studies focus on the sensory inputs from somatic areas, and less information about plastic changes in the cortex for visceral
商品
Cyclic nucleotides like cAMP modulate cell function via PKA activation and ion channels.
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