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Merck
CN

SML0025

Safinamide mesylate salt

≥98% (HPLC)

别名:

(S)-(+)-2-[[4-(3-Fluorobenzoxy)benzyl]amino]propanamide; (S)-2-[[4-[(3-Fluorobenzyl)oxy]benzyl]amino]propanamide; FCE-26743; PNU-151774E, NW-1015;

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关于此项目

经验公式（希尔记法）:
C17H19FN2O2 · xCH4O3S
化学文摘社编号:
202825-46-5
分子量:
302.34 (free base basis)
MDL编号:
MFCD15145475
UNSPSC代码:
12352200
PubChem化学物质编号:
329825096
NACRES:
NA.77

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质量水平

100

方案

≥98% (HPLC)

表单

powder

旋光性

[α]/D +9.5 to +14°, c = 1 (95% acetic acid)

颜色

white to tan

溶解性

H2O: ≥15 mg/mL

储存温度

2-8°C

SMILES字符串

CS(O)(=O)=O.C[C@H](NCc1ccc(OCc2cccc(F)c2)cc1)C(N)=O

InChI

1S/C17H19FN2O2.CH4O3S/c1-12(17(19)21)20-10-13-5-7-16(8-6-13)22-11-14-3-2-4-15(18)9-14;1-5(2,3)4/h2-9,12,20H,10-11H2,1H3,(H2,19,21);1H3,(H,2,3,4)/t12-;/m0./s1

InChI key

YKOCHIUQOBQIAC-YDALLXLXSA-N

基因信息

human ... MAOB(4129)

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相关类别

应用

Safinamide mesylate salt has been used as a reference drug to study its inhibitory effect on human monoamine oxidases (hMAO-A and hMAO-B).
Safinamide mesylate salt may be used in cell signaling studies.

生化/生理作用

Safinamide is a highly selective and reversible monoamine oxidase type B (MAO-B) inhibitor that increases neostriatal dopamine concentration. In addition, safinamide is voltage-dependent sodium and calcium channel blocker. It appears to bind to the batrachotoxin-sensitive site 2 of the voltage-sensitive sodium channels. Safinamide blocks N and L-type calcium channels and inhibits glutamate and aspartate release from synaptic terminals.
Safinamide is a sodium and calcium channel blocker that is also a selective and reversible inhibitor of monoamine oxidase type B (MAO-B); anticonvulsant
Safinamide mesylate prevents dopamine reuptake and is effective in the treatment of epilepsy and Parkinson′s disease.

特点和优势

This compound is featured on the Calcium Channels and Dopamine and Norepinephrine Metabolism pages of the Handbook of Receptor Classification and Signal Transduction. To browse other handbook pages, click here.

象形图

Health hazardExclamation mark
GHS08,GHS07

警示用语：

Warning

危险声明

H302,H319,H361d

危险分类

Acute Tox. 4 Oral - Eye Irrit. 2 - Repr. 2

储存分类代码

6.1C - Combustible acute toxic Cat.3 / toxic compounds or compounds which causing chronic effects

WGK

WGK 3

闪点(°F)

Not applicable

闪点(°C)

Not applicable

历史批次信息供参考:

分析证书(COA)

Lot/Batch Number
0000415894
0000415893
0000415894
0000415893
0000187032

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Inhibition of human monoamine oxidase: biological and molecular modeling studies on selected natural flavonoids
Carradori S, et al.
Journal of Agricultural and Food Chemistry, 64(47), 9004-9011 (2016)
Se Eun Park et al.
Journal of agricultural and food chemistry, 68(39), 10719-10729 (2020-09-02)
Luteolin, a flavonoid widely distributed in the plant kingdom, contains two benzene rings and hydroxyl groups, and this structural specificity contributes to its diverse biological activities. However, no previous studies have simultaneously investigated the therapeutic potency of luteolin isolated from
Diana Duarte et al.
International journal of molecular sciences, 22(14) (2021-07-25)
Several central nervous system (CNS) drugs exhibit potent anti-cancer activities. This study aimed to design a novel model of combination that combines different CNS agents and antineoplastic drugs (5-fluorouracil (5-FU) and paclitaxel (PTX)) for colorectal and breast cancer therapy, respectively.

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