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检测方案
≥95% (HPLC)
形式
lyophilized
组成
Peptide Content, ≥80%
储存条件
protect from light
储存温度
−20°C
基因信息
human ... CASP8(841) , CASP9(842)
Amino Acid Sequence
Ac-Leu-Glu-Thr-Asp-al
应用
Caspase 抑制剂 Ac-LETD-CHO 已被用于抑制胱天蛋白酶-8。
生化/生理作用
肽 Ac-Leu-Glu-Thr-Asp-al 或 Ac-LETD-CHO 是一种已知的半胱天冬酶抑制剂。据报道，Ac-LETD-CHO 对半胱天冬酶 8 和半胱天冬酶 9 具有抑制作用。
WGK
WGK 3
闪点(°F)
Not applicable
闪点(°C)
Not applicable
法规信息
常规特殊物品
Jie Shi et al.
Biochemical pharmacology, 75(9), 1729-1742 (2008-04-02)
Indirubin-3'-monoxime (I3M) is a derivative of indirubin, an active component from a Chinese medicinal recipe with known anti-cancer function. I3M has been well established as a cyclin-dependent kinase (CDK) inhibitor, while the molecular mechanism underlying I3M-induced apoptosis has not been
Apoptotic Regulation of Caspase Activity
Martinova, E.A., et al.
Russian J. Bioorg. Chem., 29, 471-495 (2003)
Preventive Effects of Food Components on Caspase-8-Mediated Apoptosis Induced by Dietary Carcinogen, Trp-P-1, in Rat Mononuclear Cells
Hashimoto, T., et al.
ACS Symp. Ser., 851, 128-140 (2003)
Enteric glial cells counteract Clostridium difficile Toxin B through a NADPH oxidase/ROS/JNK/caspase-3 axis, without involving mitochondrial pathways
Lara M
Scientific Reports (2017)
Takashi Araki et al.
Nephron. Experimental nephrology, 93(3), e117-e124 (2003-03-28)
Programmed cell death is a mechanism by which organisms dispose of unwanted cells, and it is thought to be an important process in organogenesis. We have already reported the role of caspase-3 in the developing metanephros. While caspase-3 is thought
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