检测方案
≥90% (HPLC)
形式
lyophilized
组成
Peptide Content, ≥75%
储存条件
protect from light
储存温度
−20°C
Amino Acid Sequence
Asp-Ala-Glu-Phe-Gly-His-Asp-Ser-Gly-Phe-Glu-Val-Arg-His-Gln-Lys-Leu-Val-Phe-Phe-Ala-Glu-Asp-Val-Gly-Ser-Asn-Lys-Gly-Ala-Ile-Ile-Gly-Leu-Met-Val-Gly-Gly-Val-Val-Ile-Ala
一般描述
淀粉样蛋白 β (Aβ) 1-42 是在阿尔茨海默病（AD）中出现的淀粉样斑块的主要成分。它具有交叉的β结构和平行的β片层
应用
大鼠淀粉样蛋白 β 1-42已被用作脑室内（ICV）注射/海马内灌注的淀粉样蛋白β （Aβ）寡聚糖，用于建立大鼠阿尔茨海默病（AD）模型。
生化/生理作用
与Aβ（1–40）相比，淀粉样蛋白 β 1-42更容易在体外形成淀粉样纤维丝。Aβ1-42注射液可导致脑功能失调，出现学习和记忆缺损。淀粉样蛋白β（Aβ）是指衍生自淀粉样前体蛋白的肽，其长度在37–43个氨基酸之间变化。Aβ（s）肽，其肽片段和突变片段用于研究广泛的代谢和调节功能，包括激酶的激活、胆固醇转运的调节、作为转录因子的功能和炎症的调节因子。Aβ（s）肽及其肽片段还用于研究氧化应激、金属结合和蛋白质交联机制，例如阿尔茨海默病和神经变性。
WGK
WGK 3
闪点(°F)
Not applicable
闪点(°C)
Not applicable
法规信息
常规特殊物品
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