生物来源
rabbit
质量水平
物料
colorless
克隆
3W5P4, monoclonal
形式
liquid
分子量
43 kDa
种属反应性
rat, human, rat
浓度
1 mg/mL
技术
immunoprecipitation (IP): 1:50 - 1:200
western blot: 1:500 - 1:1000
颜色
colorless
同位素/亚型
IgG
免疫原序列
LGTEELYGYLKKYHIDLDPHFNDILGQHSRKRWENFIHSENRHLVSPEALDLLDKLLRYDHQQRLTAKEAMEHPYFYPVVKEQSQPCADNAVLSSGLTAAR
UniProt登记号
运输
wet ice
储存温度
−20°C
靶向翻译后修饰
unmodified
基因信息
human ... CSNK2A2(1459)
一般描述
Catalytic subunit of a constitutively active serine/threonine-protein kinase complex that phosphorylates a large number of substrates containing acidic residues C-terminal to the phosphorylated serine or threonine. Regulates numerous cellular processes, such as cell cycle progression, apoptosis and transcription, as well as viral infection. May act as a regulatory node which integrates and coordinates numerous signals leading to an appropriate cellular response. During mitosis, functions as a component of the p53/TP53-dependent spindle assembly checkpoint (SAC that maintains cyclin-B-CDK1 activity and G2 arrest in response to spindle damage. Also required for p53/TP53-mediated apoptosis, phosphorylating ′Ser-392′ of p53/TP53 following UV irradiation.
免疫原
A synthetic peptide corresponding to a sequence within amino acids 250-350 of human CSNK2A2 (NP_001887.1).
PBS with 0.05% proclin300,0.05% BSA,50% glycerol,pH7.3.
应用
WB, IP
警示用语:
Warning
危险声明
危险分类
Aquatic Chronic 2 - Skin Sens. 1
WGK
WGK 3
法规信息
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