biological source
rabbit
conjugate
unconjugated
material
colorless
clone
1M1O7, monoclonal
form
liquid
mol wt
49 kDa
species reactivity
rat, rat, human
concentration
0.35 mg/mL
technique(s)
immunoprecipitation (IP): 1:50 - 1:200
western blot: 1:500 - 1:2000
color
colorless
isotype
IgG
immunogen sequence
FEYFAPDFTLHPDVSTRIENQNSRQYLDQIRQTIFENLKMLNHAPSVQIHDVPADLLTYDRTDEADAEERGPEENYSRPEAPNEFYDGDHDNDKESDVEI
UniProt accession no.
shipped in
wet ice
storage temp.
−20°C
target post-translational modification
unmodified
Quality Level
Gene Information
human ... HDAC3(8841)
Application
WB, IP
General description
Histones play a critical role in transcriptional regulation, cell cycle progression, and developmental events. Histone acetylation/deacetylation alters chromosome structure and affects transcription factor access to DNA. The protein encoded by this gene belongs to the histone deacetylase/acuc/apha family. It has histone deacetylase activity and represses transcription when tethered to a promoter. It may participate in the regulation of transcription through its binding with the zinc-finger transcription factor YY1. This protein can also down-regulate p53 function and thus modulate cell growth and apoptosis. This gene is regarded as a potential tumor suppressor gene. [provided by RefSeq, Jul 2008]
Immunogen
A synthetic peptide corresponding to a sequence within amino acids 329-428 of human HDAC3 (O15379).
PBS with 0.02% sodium azide,0.05% BSA,50% glycerol,pH7.3.
存储类别
10 - Combustible liquids
wgk
WGK 1
法规信息
常规特殊物品
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