SAB4200693
Anti-CNPase antibody, Mouse monoclonal
clone 11-5B, purified from hybridoma cell culture
别名:
2′,3′-cyclic-nucleotide 3′-phosphodiesterase, CNP, CNPase
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关于此项目
NACRES:
NA.41
UNSPSC Code:
12352203
Clone:
11-5B, monoclonal
Species reactivity:
pig (pig origin but not guinea pig), sheep, rat, bovine, rabbit, canine, human, mouse
Application:
immunoblotting
Technique(s):
immunoblotting: 5-10 μg/mL using whole rat brain extract
Citations:
6
产品名称
Anti-CNPase antibody, Mouse monoclonal, clone 11-5B, purified from hybridoma cell culture
biological source
mouse
antibody form
purified immunoglobulin
antibody product type
primary antibodies
clone
11-5B, monoclonal
form
buffered aqueous solution
mol wt
antigen 46 kDa (CNP1)
48 kDa (CNP2)
species reactivity
pig (pig origin but not guinea pig), sheep, rat, bovine, rabbit, canine, human, mouse
concentration
~1 mg/mL
technique(s)
immunoblotting: 5-10 μg/mL using whole rat brain extract
isotype
IgG1
shipped in
dry ice
storage temp.
−20°C
target post-translational modification
unmodified
Quality Level
Gene Information
human ... CNP(1267)
Application
Anti-CNPase antibody, Mouse monoclonal has been used in immunoblotting, immunohistochemistry.
Biochem/physiol Actions
CNPase (2α,3α-cyclic nucleotide 3α-phosphodiesterase), interacts with cytoskeletal proteins, cholesterol-rich cell membranes, nucleotides and various other proteins. Abnormalities in CNPase expression cause perturbations in myelin structure and are associated with neurological diseases such as schizophrenia and multiple sclerosis. It was shown that CNPase can bind Gag structural protein and prevent the assembly of HIV-1 particle, demonstrating the anti-viral activity of CNPase.
Disclaimer
Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
General description
Anti-CNPase antibody, Mouse monoclonal, (mouse IgG1 isotype) is derived from the 11-5B hybridoma produced by the fusion of mouse myeloma cells and splenocytes from RBF/Dn mouse immunized with human 2α,3α-cyclic nucleotide 3α-phosphodiesterase. CNPase (2α,3α-cyclic nucleotide 3α-phosphodiesterase), also known as CNP, is a membrane-anchored enzyme within the myelin sheath. CNPase is primarily a heterodimer of approximately 94 kDa. The heterodimer consists of a varied proportion of CNPase isoforms CNP1 (46 kDa) and CNP2 (48 kDa).
Immunogen
Human 2′,3′-cyclic nucleotide 3′-phosphodiesterase
Physical form
Solution in 0.01 M phosphate buffered saline, pH 7.4, containing 15 mM sodium azide.
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存储类别
10 - Combustible liquids
wgk
WGK 1
flash_point_f
Not applicable
flash_point_c
Not applicable
法规信息
常规特殊物品
此项目有
2?, 3?-cyclic nucleotide phosphodiesterase (CNPase) as a target in neurodegenerative diseases
Baburina Y L, et al.
Neurochemical Journal, 7(1), 1-15 (2013)
2', 3'-cyclic nucleotide 3'-phosphodiesterase, an oligodendrocyte-Schwann cell and myelin-associated enzyme of the nervous system.
Sprinkle T J.
Critical Reviews in Neurobiology, 4(3), 235-301 (1989)
Lin Chen et al.
Frontiers in aging neuroscience, 12, 590530-590530 (2020-11-17)
Running exercise, one of the strategies to protect brain function, has positive effects on neurons and synapses in the cortex and hippocampus. However, white matter, as an important structure of the brain, is often overlooked, and the effects of long-term
Inhibition of HIV-1 particle assembly by 2?, 3?-cyclic-nucleotide 3?-phosphodiesterase
Wilson S J, et al.
Cell host & microbe, 12(4), 585-597 (2012)
Activation of cannabinoid type 1 receptor (CB1) modulates oligodendroglial process branching complexity in rat hippocampal cultures stimulated by olfactory ensheathing glia-conditioned medium.
Paes-Colli, et al.
Frontiers in Cellular Neuroscience, 17, 1134130-1134130 (2023)
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