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生物来源
mouse
质量水平
偶联物
unconjugated
抗体形式
purified from hybridoma cell culture
抗体产品类型
primary antibodies
克隆
ARG1-3, monoclonal
形式
buffered aqueous solution
分子量
antigen ~40 kDa
种属反应性
rat, human, mouse
浓度
~1.0 mg/mL
技术
western blot: 2-4 μg/mL using whole extracts of rat or mouse liver.
UniProt登记号
运输
dry ice
储存温度
−20°C
靶向翻译后修饰
unmodified
基因信息
human ... ARG1(383)
一般描述
Monoclonal Anti-ARG1 (mouse IgG1 isotype) is derived from the hybridoma ARG1-3 produced by the fusion of mouse myeloma cells and splenocytes from BALB/c mice immunized with a synthetic peptide. Arginase (ARG)1 gene, codes for type I isoform of arginase. ARG1 is a cytosolic enzyme expressed predominantly in the liver as a component of the urea cycle.
免疫原
synthetic peptide corresponding to a sequence at the N-terminal region of human ARG1, conjugated to KLH. The corresponding sequence differs by 3 amino acids in mouse ARG1 and by 4 amino acids in rat ARG1.
应用
Monoclonal Anti-ARG1 antibody produced in mouse has been used in immunoblotting.
生化/生理作用
Arginase hydrolyzes arginine to ornithine and urea. Arginases have been implicated in many disease processes, including vascular diseases, pulmonary diseases, infectious diseases, immune cell dysfunction and cancer. Inherited deficiency of ARG1 enzyme results in argininemia, an autosomal recessive disorder characterized by hyperammonemia.
外形
0.01M 磷酸缓冲盐溶液，pH 7.4，含 15mM 叠氮化钠。
免责声明
Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
WGK
WGK 1
闪点(°F)
Not applicable
闪点(°C)
Not applicable
法规信息
常规特殊物品
Molecular regulation of urea cycle function by the liver glucocorticoid receptor
Okun JG, et al.
Molecular Metabolism, 4(10), 732-740 (2015)
Arginase: a critical regulator of nitric oxide synthesis and vascular function
Durante W, et al.
Clinical and Experimental Pharmacology & Physiology, 34(9), 906-911 (2007)
Xudong Sun et al.
Journal of dairy science, 107(9), 7423-7434 (2024-05-17)
Excessive concentrations of free fatty acids (FFA) are the main factors causing immune dysfunction and inflammation in dairy cows with ketosis. Polarization of macrophages (the process of macrophages freely switching from one phenotype to another) into M1 or M2 phenotypes
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