SAB4200508
Anti-ARG1 antibody, Mouse monoclonal
clone ARG1-3, purified from hybridoma cell culture
别名:
Anti-arginase-1, Anti-liver-type arginase, Anti-type I arginase, Monoclonal Anti-ARG1 antibody produced in mouse
产品名称
Anti-ARG1 antibody, Mouse monoclonal, clone ARG1-3, purified from hybridoma cell culture
biological source
mouse
conjugate
unconjugated
antibody form
purified from hybridoma cell culture
antibody product type
primary antibodies
clone
ARG1-3, monoclonal
form
buffered aqueous solution
mol wt
antigen ~40 kDa
species reactivity
rat, human, mouse
concentration
~1.0 mg/mL
technique(s)
western blot: 2-4 μg/mL using whole extracts of rat or mouse liver.
UniProt accession no.
shipped in
dry ice
storage temp.
−20°C
target post-translational modification
unmodified
Quality Level
Gene Information
human ... ARG1(383)
Application
Monoclonal Anti-ARG1 antibody produced in mouse has been used in immunoblotting.
Biochem/physiol Actions
Arginase hydrolyzes arginine to ornithine and urea. Arginases have been implicated in many disease processes, including vascular diseases, pulmonary diseases, infectious diseases, immune cell dysfunction and cancer. Inherited deficiency of ARG1 enzyme results in argininemia, an autosomal recessive disorder characterized by hyperammonemia.
Disclaimer
Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
General description
Monoclonal Anti-ARG1 (mouse IgG1 isotype) is derived from the hybridoma ARG1-3 produced by the fusion of mouse myeloma cells and splenocytes from BALB/c mice immunized with a synthetic peptide. Arginase (ARG)1 gene, codes for type I isoform of arginase. ARG1 is a cytosolic enzyme expressed predominantly in the liver as a component of the urea cycle.
Immunogen
synthetic peptide corresponding to a sequence at the N-terminal region of human ARG1, conjugated to KLH. The corresponding sequence differs by 3 amino acids in mouse ARG1 and by 4 amino acids in rat ARG1.
Physical form
Solution in 0.01 M phosphate buffered saline, pH 7.4, containing 15 mM sodium azide.
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存储类别
12 - Non Combustible Liquids
wgk
WGK 1
flash_point_f
Not applicable
flash_point_c
Not applicable
法规信息
常规特殊物品
此项目有
Molecular regulation of urea cycle function by the liver glucocorticoid receptor
Okun JG, et al.
Molecular Metabolism, 4(10), 732-740 (2015)
Arginase: a critical regulator of nitric oxide synthesis and vascular function
Durante W, et al.
Clinical and Experimental Pharmacology & Physiology, 34(9), 906-911 (2007)
Xudong Sun et al.
Journal of dairy science, 107(9), 7423-7434 (2024-05-17)
Excessive concentrations of free fatty acids (FFA) are the main factors causing immune dysfunction and inflammation in dairy cows with ketosis. Polarization of macrophages (the process of macrophages freely switching from one phenotype to another) into M1 or M2 phenotypes
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