SAB4200500
抗-胶原IV抗体，小鼠单克隆
clone J3-2, purified from hybridoma cell culture
别名:
单克隆抗-胶原蛋白IV 小鼠抗, 抗-COL4
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关于此项目
NACRES:
NA.41
UNSPSC Code:
12352203
Conjugate:
unconjugated
Clone:
J3-2, monoclonal
Application:
immunohistochemistry
western blot
western blot
Species reactivity:
mouse, rat, dog, bovine, human, monkey
Citations:
20
Technique(s):
immunohistochemistry: 2.0-4.0 μg/mL using human liver tissue sections.
western blot: 1.0-2.0 μg/mL using human placenta extracts.
western blot: 1.0-2.0 μg/mL using human placenta extracts.
产品名称
抗-胶原IV抗体，小鼠单克隆, clone J3-2, purified from hybridoma cell culture
biological source
mouse
conjugate
unconjugated
antibody form
purified from hybridoma cell culture
antibody product type
primary antibodies
clone
J3-2, monoclonal
form
buffered aqueous solution
species reactivity
mouse, rat, dog, bovine, human, monkey
concentration
~1.0 mg/mL
technique(s)
immunohistochemistry: 2.0-4.0 μg/mL using human liver tissue sections.
western blot: 1.0-2.0 μg/mL using human placenta extracts.
shipped in
dry ice
storage temp.
−20°C
target post-translational modification
unmodified
Quality Level
Gene Information
human ... COL4A1(1282)
Application
小鼠抗IV型胶原单克隆抗体可用于：
- 免疫组织化学染色
- 免疫染色
- 免疫荧光检测
- 作为免疫印迹分析的二抗
Biochem/physiol Actions
胶原蛋白IV在基底膜组装中起关键作用。六个链组装成三个不同的原体，即α 1.α1.α2（IV）、α3.α4.α5（IV）和α 5.α5.α6（IV）。三聚体以α-链的不同组合形成。在专门的肾小球BM（GBM）中观察到α3、α4和α5的高表达水平。COlA5基因的突变与Alport综合征有关，而α3（IV）链与Goodpasture综合征（一种自身免疫性疾病）的发病机制有关。COlA5中的突变也与弥漫性食管平滑肌瘤病有关。
Disclaimer
除非我们的产品目录或产品附带的其他公司文档另有说明，否则我们的产品仅供研究使用，不得用于任何其他目的，包括但不限于未经授权的商业用途、体外诊断用途、离体或体内治疗用途或任何类型的消费或应用于人类或动物。
General description
人胶原IV包含六个基因。COL4A1-COL4A2定位于13号染色体。COL4A3-COL4A4和COL4A5-COL4A6分别位于2号染色体和X号染色体上。它属于胶原超家族，并与基底膜（BMs）相关。六个α链，即α1（IV）至α6（IV）包含N端半胱氨酸和赖氨酸结构域，典型的Gly-X-Y三重重复序列和C端非胶原（NC1）结构域。
Immunogen
胎盘制剂富含基底膜胶原蛋白。
Physical form
0.01M 磷酸缓冲盐溶液，pH 7.4，含 15mM 叠氮化钠。
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存储类别
10 - Combustible liquids
wgk
WGK 2
flash_point_f
Not applicable
flash_point_c
Not applicable
法规信息
常规特殊物品
此项目有
Mammalian collagen IV
Khoshnoodi J, et al.
Microscopy Research and Technique, 71(5), 357-370 (2008)
Lysyl hydroxylase inhibition by minoxidil blocks collagen deposition and prevents pulmonary fibrosis via TGF-beta1/Smad3 signaling pathway
Shao S, et al.
Medical Science Monitor : International Medical Journal of Experimental and Clinical Research, 24(2), 8592-8592 (2018)
Type IV collagen: structure, gene organization, and role in human diseases. Molecular basis of Goodpasture and Alport syndromes and diffuse leiomyomatosis.
Hudson BG, et al.
The Journal of Biological Chemistry, 268(35), 26033-26036 (1993)
Collagen IV is essential for basement membrane stability but dispensable for initiation of its assembly during early development
Poschl E, et al.
Development, 131(7), 1619-1628 (2004)
Monica S Schoenenberger et al.
The FEBS journal, 291(3), 477-488 (2023-11-21)
Basement membranes are among the most widespread, non-cellular functional materials in metazoan organisms. Despite this ubiquity, the links between their compositional and biophysical properties are often difficult to establish due to their thin and delicate nature. In this article, we
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