推荐产品
生物来源
rabbit
质量水平
偶联物
unconjugated
抗体形式
affinity isolated antibody
抗体产品类型
primary antibodies
克隆
polyclonal
形式
buffered aqueous solution
分子量
antigen 34-37 kDa
种属反应性
human, rat, mouse
浓度
~1 mg/mL
技术
flow cytometry: 1:200-1:500
immunohistochemistry: 1:100-1:200
western blot: 1:500-1:1,000
UniProt登记号
运输
dry ice
储存温度
−20°C
靶向翻译后修饰
unmodified
基因信息
human ... SOX2(6657)
mouse ... Sox2(20674)
rat ... Sox2(499593)
相关类别
一般描述
转录因子SOX-2（SOX-2）是SRY相关HMG-box（SOX）转录因子家族的成员，参与调节胚胎发育和确定细胞命运。该基因的突变与双侧失语症有关，双侧失语症是结构性眼畸形的一种严重形式。当SOX-2在自我更新的祖细胞中表达时，它起到抑制神经元分化的作用。相反，SOX-2的主动抑制诱导神经分化。
特异性
兔多克隆抗SOX2抗体可识别人，小鼠，大鼠性别决定区Y-box 2转录因子。
免疫原
对应于人SOX2残基32-47的合成肽。
应用
兔多克隆抗Sox2抗体用于标记溶质性别决定区Y-box 2转录因子，以通过免疫细胞化学和免疫组织化学（IHC）技术（例如免疫印迹（~37 kDa）和流式细胞术）进行检测和定量。 它被用作探针来确定性别决定区Y-box 2转录因子在祖细胞自我更新和分化中的存在和作用。
外形
溶于含有 0.02％ 叠氮化钠的磷酸盐缓冲液中。
免责声明
除非我们的产品目录或产品附带的其他公司文档另有说明，否则我们的产品仅供研究使用，不得用于任何其他目的，包括但不限于未经授权的商业用途、体外诊断用途、离体或体内治疗用途或任何类型的消费或应用于人类或动物。
WGK
nwg
闪点(°F)
Not applicable
闪点(°C)
Not applicable
个人防护装备
Eyeshields, Gloves, multi-purpose combination respirator cartridge (US)
法规信息
常规特殊物品
Bartolo Bono et al.
Scientific reports, 8(1), 13838-13838 (2018-09-16)
Cancer stem cells (CSCs) have been involved in the maintenance, progression and relapse of several tumors, but their origin is still elusive. Here, in vitro transformed human fibroblasts (cen3tel cells) and the tumorsphere assay were used to search for and
Elisa Latorre et al.
Molecular pharmacology, 89(2), 243-252 (2015-12-18)
Since 2005, sex determining region y-box 2 (SOX2) has drawn the attention of the scientific community for being one of the key transcription factors responsible for pluripotency induction in somatic stem cells. Our research investigated the turnover regulation of SOX2
Dasa Dolezalova et al.
Stem cells (Dayton, Ohio), 30(7), 1362-1372 (2012-04-19)
Studies of human embryonic stem cells (hESCs) commonly describe the nonfunctional p53-p21 axis of the G1/S checkpoint pathway with subsequent relevance for cell cycle regulation and the DNA damage response (DDR). Importantly, p21 mRNA is clearly present and upregulated after
Martyna Łupicka et al.
Reproduction (Cambridge, England), 149(4), 317-327 (2015-01-04)
The aim of this study was to identify uterine pluripotent cells both in bovine uterine tissues as well in epithelial, stromal, and myometrial uterine cell populations. Moreover, the relationship of pluripotent markers expression with age and the uterine horn side
Martyna Łupicka et al.
Reproductive biology and endocrinology : RB&E, 13, 110-110 (2015-09-30)
Adenomyosis is a proliferative uterine dysfunction with unknown aetiology. One possible mechanism of its development involves disturbances in stem cell differentiation in uterine tissue. Previously, we identified pluripotent/multipotent cells in the bovine uterus, therefore our present study focused on determining
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