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质量水平
检测方案
≥98% (HPLC)
形式
powder
颜色
white
溶解性
DMSO: >10 mg/mL
H2O: insoluble
创始人
Sanofi Aventis
SMILES字符串
OC(=O)C(O)=O.CCc1ccccc1OC[C@@H](O)CN[C@H]2CCCc3ccccc23
InChI
1S/C21H27NO2.C2H2O4/c1-2-16-8-4-6-13-21(16)24-15-18(23)14-22-20-12-7-10-17-9-3-5-11-19(17)20;3-1(4)2(5)6/h3-6,8-9,11,13,18,20,22-23H,2,7,10,12,14-15H2,1H3;(H,3,4)(H,5,6)/t18-,20-;/m0./s1
InChI key
XTBQNQMNFXNGLR-MKSBGGEFSA-N
基因信息
human ... ADRB3(155)
应用
SR 59230A用于& # 946；大鼠主动脉中的肾上腺素受体。3经测试，它被认为是一种改善心力衰竭大鼠模型心脏功能的潜在治疗剂。4
生化/生理作用
SR 59230A是一种& # 946；3-肾上腺素受体拮抗剂。它对& # 946；有很高的亲和力。3肾上腺素能受体出现在人体肠道中，影响人体结肠循环平滑肌的功能。1据报道SR 59230A抑制心脏钾通道2.1-2.3。2
特点和优势
该化合物由Sanofi Aventis开发。要浏览其他药物开发化合物和批准的药物/候选药物列表，单击此处。
WGK
WGK 3
闪点(°F)
Not applicable
闪点(°C)
Not applicable
个人防护装备
Eyeshields, Gloves, type N95 (US)
Maria Antonietta Maselli et al.
European journal of pharmacology, 723, 62-66 (2013-11-28)
The effect of two novel β3-adrenoceptor (β3-AR) agonists SP-1f and SP-1h on human colon circular smooth muscle contractility and β3-AR mRNA expression have been determined. β3-AR is ascertained co-participates to the control of the gut motility. Isometric tension on human
F De Ponti et al.
British journal of pharmacology, 117(7), 1374-1376 (1996-04-01)
The role of beta 3-adrenoceptors in human colonic circular smooth muscle was assessed in vitro by use of the beta 3-selective antagonist SR 59230A. Isoprenaline, in the presence of the selective beta-adrenoceptor antagonists CGP 20712A (beta 1) and ICI 118551
Martin Kulzer et al.
Biochemical and biophysical research communications, 424(2), 315-320 (2012-07-04)
Kir2.x channels form the molecular basis of cardiac I(K1) current and play a major role in cardiac electrophysiology. However, there is a substantial lack of selective Kir2 antagonists. We found the β(3)-adrenoceptor antagonist SR59230A to be an inhibitor of Kir2.x
Maura Calvani et al.
British journal of pharmacology, 176(14), 2509-2524 (2019-03-16)
Stress-related catecholamines have a role in cancer and β-adrenoceptors; specifically, β2 -adrenoceptors have been identified as new targets in treating melanoma. Recently, β3 -adrenoceptors have shown a pleiotropic effect on melanoma micro-environment leading to cancer progression. However, the mechanisms by
Run-tao Gan et al.
Chinese medical journal, 120(24), 2250-2255 (2008-01-03)
Stimulation of the heart beta 3-adrenoceptor (AR) may result in a negative inotropic effect. Being up-regulated, beta 3-AR plays a more important role in the regulation of cardiac function during heart failure. However, the effect of chronic blocking of beta
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