S8688
SR 59230A
≥98% (HPLC), powder, β3-Adrenoceptor antagonist
别名:
3-（2-乙基苯氧基）-1-[[（1S）-1,2,3,4-四氢萘-1-基]氨基]-（2S）-2-丙醇 草酸盐
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关于此项目
经验公式（希尔记法）:
C21H27NO2 · C2H2O4
化学文摘社编号:
分子量:
415.48
UNSPSC Code:
12352200
PubChem Substance ID:
NACRES:
NA.77
MDL number:
产品名称
SR 59230A, ≥98% (HPLC), powder
SMILES string
OC(=O)C(O)=O.CCc1ccccc1OC[C@@H](O)CN[C@H]2CCCc3ccccc23
InChI key
XTBQNQMNFXNGLR-MKSBGGEFSA-N
InChI
1S/C21H27NO2.C2H2O4/c1-2-16-8-4-6-13-21(16)24-15-18(23)14-22-20-12-7-10-17-9-3-5-11-19(17)20;3-1(4)2(5)6/h3-6,8-9,11,13,18,20,22-23H,2,7,10,12,14-15H2,1H3;(H,3,4)(H,5,6)/t18-,20-;/m0./s1
assay
≥98% (HPLC)
form
powder
color
white
solubility
DMSO: >10 mg/mL, H2O: insoluble
originator
Sanofi Aventis
Quality Level
Gene Information
human ... ADRB3(155)
相关类别
Application
SR 59230A用于& # 946；大鼠主动脉中的肾上腺素受体。3经测试，它被认为是一种改善心力衰竭大鼠模型心脏功能的潜在治疗剂。4
Biochem/physiol Actions
SR 59230A是一种& # 946；3-肾上腺素受体拮抗剂。它对& # 946；有很高的亲和力。3肾上腺素能受体出现在人体肠道中，影响人体结肠循环平滑肌的功能。1据报道SR 59230A抑制心脏钾通道2.1-2.3。2
Features and Benefits
该化合物由Sanofi Aventis开发。要浏览其他药物开发化合物和批准的药物/候选药物列表，单击此处。
存储类别
11 - Combustible Solids
wgk
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
ppe
Eyeshields, Gloves, type N95 (US)
Run-tao Gan et al.
Chinese medical journal, 120(24), 2250-2255 (2008-01-03)
Stimulation of the heart beta 3-adrenoceptor (AR) may result in a negative inotropic effect. Being up-regulated, beta 3-AR plays a more important role in the regulation of cardiac function during heart failure. However, the effect of chronic blocking of beta
Maura Calvani et al.
British journal of pharmacology, 176(14), 2509-2524 (2019-03-16)
Stress-related catecholamines have a role in cancer and β-adrenoceptors; specifically, β2 -adrenoceptors have been identified as new targets in treating melanoma. Recently, β3 -adrenoceptors have shown a pleiotropic effect on melanoma micro-environment leading to cancer progression. However, the mechanisms by
Maura Calvani et al.
Frontiers in immunology, 11, 2098-2098 (2020-09-29)
Understanding the mechanisms of immune tolerance is currently one of the most important challenges of scientific research. Pregnancy affects the immune system balance, leading the host to tolerate embryo alloantigens. Previous reports demonstrated that β-adrenergic receptor (β-AR) signaling promotes immune
Maria Antonietta Maselli et al.
European journal of pharmacology, 723, 62-66 (2013-11-28)
The effect of two novel β3-adrenoceptor (β3-AR) agonists SP-1f and SP-1h on human colon circular smooth muscle contractility and β3-AR mRNA expression have been determined. β3-AR is ascertained co-participates to the control of the gut motility. Isometric tension on human
Elena Butturini et al.
European journal of pharmacology, 730, 107-115 (2014-03-15)
The aim of this study was to investigate the effect of costunolide (CS) and dehydrocostuslactone (DCE) a well-known sesquiterpene lactones contained in many plants, in a model of lung injury induced by carrageenan administration in the mice. Injection of carrageenan
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