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Merck
CN

S8502

(−)-Scopolamine methyl bromide

≥98% (HPLC), mAChRs antagonist, powder

别名:

Hyoscine methyl bromide, Methscopolamine bromide

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关于此项目

经验公式（希尔记法）:
C18H24NO4 · Br
化学文摘社编号:
155-41-9
分子量:
398.29
NACRES:
NA.77
PubChem Substance ID:
24278714
UNSPSC Code:
12352116
EC Number:
205-844-5
MDL number:
MFCD00078560

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产品名称

(−)-Scopolamine methyl bromide, ≥98% (HPLC), powder

InChI key

CXYRUNPLKGGUJF-RAFJPFSSSA-M

InChI

1S/C18H24NO4.BrH/c1-19(2)14-8-12(9-15(19)17-16(14)23-17)22-18(21)13(10-20)11-6-4-3-5-7-11;/h3-7,12-17,20H,8-10H2,1-2H3;1H/q+1;/p-1/t12-,13-,14-,15+,16-,17+;/m1./s1

SMILES string

[Br-].[H][C@]12C[C@@H](C[C@]([H])([C@@]3([H])O[C@@]13[H])[N+]2(C)C)OC(=O)[C@H](CO)c4ccccc4

assay

≥98% (HPLC)

form

powder

optical activity

[α]25/D −25°, c = 5 in H2O(lit.)

color

white

solubility

H2O: 50 mg/mL

Quality Level

200

Gene Information

human ... CHRM1(1128), CHRM2(1129), CHRM3(1131), CHRM4(1132), CHRM5(1133)

相关类别

Application

(−)-Scopolamine methyl bromide was administered to rats to inhibit the peripheral cholinergic effects induced by pilocarpine.10,11

Biochem/physiol Actions

Competitive muscarinic acetylcholine receptor antagonist.
Scopolamine is an anti-muscarinic and cholinolytic alkaloid that inhibits parasympathetic-cholinergic system.7 The central effects include hallucinations, disorientation, restlessness and euphoria.8 Scopolamine disturb the stimulus detection performance in rats by interfering with the reticular cholinergic pathways.9

Disclaimer

Shelf-life of the powder is at least five years when stored at room temperature.

pictograms

Exclamation markEnvironment
GHS07,GHS09

signalword

Warning

Hazard Classifications

Acute Tox. 4 Dermal - Acute Tox. 4 Inhalation - Aquatic Acute 1

存储类别

11 - Combustible Solids

wgk

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

ppe

dust mask type N95 (US), Eyeshields, Gloves

法规信息

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分析证书(COA)

Lot/Batch Number
0000190854
0000253869
0000241910
0000190854
0000253869

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