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质量水平
方案
≥98% (HPLC)
表单
powder
旋光性
[α]25/D −25°, c = 5 in H2O(lit.)
颜色
white
溶解性
H2O: 50 mg/mL
SMILES字符串
[Br-].[H][C@]12C[C@@H](C[C@]([H])([C@@]3([H])O[C@@]13[H])[N+]2(C)C)OC(=O)[C@H](CO)c4ccccc4
InChI
1S/C18H24NO4.BrH/c1-19(2)14-8-12(9-15(19)17-16(14)23-17)22-18(21)13(10-20)11-6-4-3-5-7-11;/h3-7,12-17,20H,8-10H2,1-2H3;1H/q+1;/p-1/t12-,13-,14-,15+,16-,17+;/m1./s1
InChI key
CXYRUNPLKGGUJF-RAFJPFSSSA-M
基因信息
human ... CHRM1(1128) , CHRM2(1129) , CHRM3(1131) , CHRM4(1132) , CHRM5(1133)
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应用
(−)-Scopolamine methyl bromide was administered to rats to inhibit the peripheral cholinergic effects induced by pilocarpine.10,11
生化/生理作用
Competitive muscarinic acetylcholine receptor antagonist.
Scopolamine is an anti-muscarinic and cholinolytic alkaloid that inhibits parasympathetic-cholinergic system.7 The central effects include hallucinations, disorientation, restlessness and euphoria.8 Scopolamine disturb the stimulus detection performance in rats by interfering with the reticular cholinergic pathways.9
注意
Shelf-life of the powder is at least five years when stored at room temperature.
警示用语：
Warning
危险声明
危险分类
Acute Tox. 4 Dermal - Acute Tox. 4 Inhalation - Aquatic Acute 1
储存分类代码
11 - Combustible Solids
WGK
WGK 3
闪点(°F)
Not applicable
闪点(°C)
Not applicable
个人防护装备
dust mask type N95 (US), Eyeshields, Gloves
法规信息
新产品
从最新的版本中选择一种：
分析证书(COA)
Lot/Batch Number
Michal Kielbinski et al.
Developmental neurobiology, 78(7), 718-735 (2018-04-18)
Malformations of cortical development (MCD) are a common cause of intractable seizures in humans. Among these, focal cortical dysplasia (FCD) poses an outstanding challenge. There are several subtypes of FCD that show significant variation in pathology and clinical presentation. All
Nicholas H Varvel et al.
Neuropharmacology, 224, 109356-109356 (2022-12-03)
Cognitive comorbidities can substantially reduce quality of life in people with epilepsy. Inflammation is a component of all chronic diseases including epilepsy, as well as acute events like status epilepticus (SE). Neuroinflammation is the consequence of several broad signaling cascades
Zuzanna Setkowicz et al.
Epilepsia, 44(10), 1267-1273 (2003-09-27)
To determine whether brains irradiated at different stages of prenatal development also have different postnatal susceptibility to seizures evoked by pilocarpine. Pregnant Wistar rats were exposed to a single 1.0-Gy dose of gamma rays on gestation days 13, 15, 17
Misty M Strain et al.
iScience, 27(3), 109137-109137 (2024-02-29)
Cardiovagal neurons (CVNs) innervate cardiac ganglia through the vagus nerve to control cardiac function. Although the cardioinhibitory role of CVNs in nucleus ambiguus (CVNNA) is well established, the nature and functionality of CVNs in dorsal motor nucleus of the vagus
Philipp Singer et al.
Pharmacology, biochemistry, and behavior, 101(1), 107-114 (2012-01-03)
Prepulse inhibition (PPI) of the acoustic startle reflex refers to the reduction of the startle response to an intense acoustic pulse stimulus when it is shortly preceded by a weak non-startling prepulse stimulus and provides a cross-species measure of sensory-motor
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