product name
SU 5416, ≥98% (HPLC)
质量水平
检测方案
≥98% (HPLC)
形式
powder
颜色
yellow to yellow-orange
mp
221-222 °C
溶解性
DMSO: 20 mg/mL, clear (warmed)
H2O: insoluble
储存温度
−20°C
SMILES字符串
Cc1cc(C)c(C=C2C(=O)Nc3ccccc23)[nH]1
InChI
1S/C15H14N2O/c1-9-7-10(2)16-14(9)8-12-11-5-3-4-6-13(11)17-15(12)18/h3-8,16H,1-2H3,(H,17,18)/b12-8+
InChI key
WUWDLXZGHZSWQZ-XYOKQWHBSA-N
基因信息
human ... EGFR(1956) , FLT1(2321) , IGFBP1(3484) , IL2(3558) , KDR(3791) , PDGFRB(5159)
mouse ... Flt1(14254) , Kdr(16542)
一般描述
SU 5416是一种血管内皮生长因子（VEGF）受体蛋白酪氨酸激酶1/2抑制剂。SU 5416可以抑制肿瘤生长和肿瘤血管新生。SU 5416抑制神经元型一氧化氮合酶活性，保护神经元细胞免遭一氧化氮介导的神经毒性伤害。也用作芳烃受体激动剂，还可能作为临床药物，有效治疗自身免疫疾病和移植排斥。
应用
SU 5416已用于在血管形成试验前处理人脐静脉内皮细胞(HUVEC)，评估它对血管形成网络的影响。可诱发小鼠的肺动脉高压(PH)成为实验模型。
生化/生理作用
SU 516可抑制神经元一氧化氮合酶的活性并保护神经元细胞免受一氧化氮介导的神经毒性的影响。1 它还可作为芳烃受体的激动剂，是治疗自身免疫疾病和移植排斥的有效临床试剂。2
SU 5416是一种血管内皮生长因子（VEGF）受体蛋白酪氨酸激酶1/2抑制剂。
特点和优势
该化合物是激酶磷酸酶生物学研究的推荐产品。点击这里 发现更多精选激酶磷酸酶生物学产品。了解更多有关用于其他研究领域的生物活性小分子的信息，请访问 sigma.com/discover-bsm。
WGK
WGK 3
个人防护装备
dust mask type N95 (US), Eyeshields, Gloves
Joshua D Mezrich et al.
PloS one, 7(9), e44547-e44547 (2012-09-13)
The experimental compound SU5416 went as far as Phase III clinical trials as an anticancer agent, putatively because of its activity as a VEGFR-2 inhibitor, but showed poor results. Here, we show that SU5416 is also an aryl hydrocarbon receptor
Florian Ulrich et al.
Developmental biology, 357(1), 134-151 (2011-07-13)
The brain is made of billions of highly metabolically active neurons whose activities provide the seat for cognitive, affective, sensory and motor functions. The cerebral vasculature meets the brain's unusually high demand for oxygen and glucose by providing it with
Charlene Watterston et al.
PLoS genetics, 17(8), e1009769-e1009769 (2021-08-24)
Vessel growth integrates diverse extrinsic signals with intrinsic signaling cascades to coordinate cell migration and sprouting morphogenesis. The pro-angiogenic effects of Vascular Endothelial Growth Factor (VEGF) are carefully controlled during sprouting to generate an efficiently patterned vascular network. We identify
Yong Liu et al.
Journal of orthopaedic translation, 23, 29-37 (2020-06-02)
Accelerating the process of bone regeneration is of great interest for surgeons and basic scientists alike. Recently, umbilical cord mesenchymal stem cells (UCMSCs) are considered clinically applicable for tissue regeneration due to their noninvasive harvesting and better viability. Nonetheless, the
Hidenori Moriyama et al.
Nature communications, 13(1), 3013-3013 (2022-06-01)
Pulmonary hypertension is a fatal rare disease that causes right heart failure by elevated pulmonary arterial resistance. There is an unmet medical need for the development of therapeutics focusing on the pulmonary vascular remodeling. Bioactive lipids produced by perivascular inflammatory
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