产品名称
抗 物质P受体 兔抗, IgG fraction of antiserum, buffered aqueous solution
biological source
rabbit
conjugate
unconjugated
antibody form
IgG fraction of antiserum
antibody product type
primary antibodies
clone
polyclonal
form
buffered aqueous solution
mol wt
antigen 46 kDa
species reactivity
human, rat, mouse, guinea pig
packaging
antibody small pack of 25 μL
technique(s)
immunohistochemistry (frozen sections): 1:5,000 using 4% paraformaldehyde (with picric acid/glutaraldehyde)-fixed, frozen, rat brain sections.
microarray: suitable
western blot (chemiluminescent): 1:2,000 using a rat brain membrane fraction extract
UniProt accession no.
shipped in
dry ice
storage temp.
−20°C
target post-translational modification
unmodified
Quality Level
Gene Information
human ... TACR1(6869)
mouse ... Tacr1(21336)
rat ... Tacr1(24807)
Application
兔抗P物质受体抗体可用于免疫组化。
Biochem/physiol Actions
P物质（SP）具有促炎、内分泌、神经调节和营养活性。P物质受体（SPR）与配体SP结合后，会促进粒细胞外渗和炎症及组织紊乱。另外，该受体激活还可增强磷酸肌醇代谢，合成1,4,5-三磷酸肌醇和二酰基甘油，从而导致内质网释放Ca2+并激活蛋白激酶C。 SPR及其配体可刺激多种癌症的肿瘤血管生成和细胞增殖。抑制P物质受体可抑制神经母细胞瘤（NB）细胞的生长。因此，SPR可能是多种神经母细胞瘤患者的潜在治疗靶点。SP-SPR复合物还参与疼痛传递的调节。
Disclaimer
除非我们的产品目录或产品附带的其他公司文档另有说明，否则我们的产品仅供研究使用，不得用于任何其他目的，包括但不限于未经授权的商业用途、体外诊断用途、离体或体内治疗用途或任何类型的消费或应用于人类或动物。
General description
P物质受体（SPR），又称神经激肽受体1（NK-1 R），是具有7个跨膜结构域的G蛋白偶联受体家族的成员。SPR基因有5个外显子，基因组DNA跨越45-60kb，定位于人类2号染色体。SPR在中枢神经系统中高度表达。
Immunogen
对应于大鼠NK1R C端的合成肽（氨基酸393-407）。该序列在小鼠、豚鼠和人NK1R中高度保守，但在其他速激肽受体亚型NK2R和NK3R中有差异。
Physical form
0.01M 磷酸缓冲盐溶液，pH 7.4，含 15mM 叠氮化钠。
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存储类别
10 - Combustible liquids
wgk
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
法规信息
常规特殊物品
此项目有
Expression of Truncated Neurokinin-1 Receptor in Childhood Neuroblastoma is Independent of Tumor Biology and Stage.
Pohl A, et al.
Anticancer Research, 37, 6079-6085 (2017)
Human substance P receptor (NK-1): organization of the gene, chromosome localization, and functional expression of cDNA clones.
Gerard NP, et al.
Biochemistry, 30, 10640-10646 (1991)
Keith B Hengen et al.
PloS one, 10(3), e0119351-e0119351 (2015-03-10)
The parameters governing GABAA receptor subtype expression patterns are not well understood, although significant shifts in subunit expression may support key physiological events. For example, the respiratory control network in pregnant rats becomes relatively insensitive to barbiturates due to increased
Neurokinin 1 and opioid receptors: relationships and interactions in nervous system
Xiao, Jie, et al
Translational perioperative and pain medicine, 1, 11-21 (2016)
Abeer W Saeed et al.
The Journal of comparative neurology, 521(8), 1915-1928 (2012-11-23)
Lamina I of the spinal dorsal horn is a major site of integration and transmission to higher centers of nociceptive information from the periphery. One important primary afferent population that transmits such information to the spinal cord expresses substance P
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