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质量水平
检测方案
≥95% (HPLC)
形式
solid
溶解性
DMSO: soluble
储存温度
−20°C
SMILES字符串
CC(NC(=O)c1ccccc1\N=C\c2c(O)ccc3ccccc23)c4ccccc4
InChI
1S/C26H22N2O2/c1-18(19-9-3-2-4-10-19)28-26(30)22-13-7-8-14-24(22)27-17-23-21-12-6-5-11-20(21)15-16-25(23)29/h2-18,29H,1H3,(H,28,30)/b27-17+
InChI key
UXJFDYIHRJGPFS-WPWMEQJKSA-N
基因信息
human ... SIRT1(23411) , SIRT2(22933)
应用
用sirtinol处理HUVEC以研究转录因子Krüppel样因子2的诱导作用。4 Sirtinol可用于处理人胚肾细胞,以研究其对Werner综合征蛋白表达的影响。5
生化/生理作用
Sirtinol可在 体内抑制酵母Sir2p转录沉默活性, 体外抑制酵母Sir2p和人SIRT2脱乙酰酶活性。它可抑制血小板聚集的生理调节剂(如凝血酶和胶原蛋白),减弱细胞内Ca2+的释放并形成血栓素B2。它可以通过抑制cAMP磷酸二酯酶来增加cAMP的水平并抑制血小板的聚集。2 Sirtinol可降低人皮肤微血管内皮细胞对TNF-α 和IL-1β的炎症反应。3
Sirtinol可在 体内抑制酵母Sir2p转录沉默活性, 体外抑制酵母Sir2p和人SIRT2脱乙酰酶活性。
特点和优势
这种化合物是基因调控研究的特色产品。点击此处发现更多特色基因调控产品。在sigma.com/discover-bsm可了解更多关于生物活性小分子的其他研究领域。
WGK
WGK 3
闪点(°F)
Not applicable
闪点(°C)
Not applicable
个人防护装备
Eyeshields, Gloves, type N95 (US)
PloS one, 6(9), e24307-e24307 (2011-09-21)
Histone deacetylases (HDAC) are key enzymes in the epigenetic control of gene expression. Recently, inhibitors of class I and class II HDAC have been successfully employed for the treatment of different inflammatory diseases such as rheumatoid arthritis, colitis, airway inflammation
The American journal of physiology, 261(1 Pt 1), G65-G70 (1991-07-01)
We examined the role of reduced glutathione as a defense mechanism against acid-induced gastric mucosal cell damage in vitro. Cellular stores of reduced glutathione were depleted by reaction with diethyl maleate (DEM) or 1-chloro-2,4-dinitrobenzene (CDNB) and increased by reaction with
Aging cell, 18(2), e12904-e12904 (2019-01-08)
Although it is known that the expression and activity of sirtuin 1 (Sirt1) decrease in the aged kidney, the role of interaction between Sirt1 and hypoxia-inducible factor (HIF)-1α is largely unknown. In this study, we investigated whether HIF-1α could be
International immunopharmacology, 45, 135-147 (2017-02-19)
Osteoarthritis (OA) is a degenerative joint disease characterized by cartilage degradation and inflammation. Fisetin, a polyphenol extracted from fruits and vegetables, has been reported to have anti-inflammatory effects. Our study aimed to investigate the effect of fisetin on OA both
Biochemical pharmacology, 153, 282-291 (2018-02-11)
Leptin, a representative adipokine secreted from the white adipose tissue, is considered as a potential linker between obesity and cancer. SIRT1 is an NAD+-dependent histone/protein deacetylase speculated to function as an oncogene. In the present study, we found that leptin
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