形式
lyophilized powder
质量水平
比活
≥100 units/mg protein
分子量
36873 Da
组成
Protein, ~10% Lowry
储存温度
2-8°C
基因信息
Bacillus cereus ATCC 14579 ... BC0671(1203022)
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一般描述
蜡状芽孢杆菌的鞘磷脂酶（Bc-Smase）是一种含Mg2+的金属酶。 蜡状芽孢杆菌 的鞘磷脂酶诱导绵羊红细胞的溶血。
鞘磷脂酶调节成纤维细胞和巨噬细胞大囊泡不依赖三磷酸腺苷（ATP）的内吞作用。鞘磷脂酶引起人红细胞溶血。 它也是导致侵入性疾病的有效毒力因子。
应用
来自 蜡样芽孢杆菌 的鞘磷脂酶已被用于：
- 测定脑片中的膜电容
- 在酶活性测定中检测并证实其杀蚕活性
- 用于阐明其对复合脂类混合物中鞘磷脂水解的影响
鞘磷脂酶已被用于一项研究中，用于研究患儿和成年尼曼匹克病患者的骨骼表现。
生化/生理作用
启动形成基于鞘磷脂的第二信使。激活 MAPK（丝裂原活化蛋白激酶）和 SAPKs（压力激活蛋白激酶）；从鞘磷脂生成神经酰胺。
单位定义
在 pH 7.8、25°C 条件下，1 个单位将每分钟水解1.0μmolTNPAL-鞘磷脂。
外形
冻干粉，含磷酸钾缓冲盐和稳定剂。
警示用语：
Warning
危险声明
危险分类
Skin Sens. 1
WGK
WGK 3
闪点(°F)
Not applicable
闪点(°C)
Not applicable
个人防护装备
Eyeshields, Gloves, type N95 (US)
法规信息
常规特殊物品
Masataka Oda
Yakugaku zasshi : Journal of the Pharmaceutical Society of Japan, 129(10), 1233-1238 (2009-10-03)
Bacillus cereus is one that causes of opportunistic human infections. Sphingomyelinase produced by B. cereus is assumed a virulence factor for the infection. Sphingomyelinase from Bacillus cereus (Bc-SMase) is Mg(2+)-containing metalloenzyme. Bc-SMase is a family of neutral SMase (nSMase) and
Masataka Oda et al.
Biochimica et biophysica acta, 1798(6), 1073-1080 (2010-03-11)
Bacillus cereus sphingomyelinase (Bc-SMase) induces hemolysis of sheep erythrocytes which contain large amounts of sphingomyelin. We investigated the mechanism of this hemolysis in comparison to that induced by Clostridium perfringens alpha-toxin. Pertussis toxin, a Gi-specific inhibitor, N-oleoylethernolamine, a ceramidase inhibitor
Lipid bilayers containing sphingomyelins and ceramides of varying N-acyl lengths: a glimpse into sphingolipid complexity
Jimenez-Rojo N, et al.
Biochimica et Biophysica Acta - Biomembranes, 1838(1), 456-464 (2014)
Purification of a soil bacteria exotoxin using silkworm toxicity to measure specific activity
Usui K, et al.
Microbial Pathogenesis, 46(2), 59-62 (2009)
Melissa Wasserstein et al.
Journal of inherited metabolic disease, 36(1), 123-127 (2012-06-22)
Niemann-Pick disease (NPD) due to acid sphingomyelinase deficiency is a lipid storage disease resulting from the accumulation of sphingomyelin, predominantly within cells of the monocyte-macrophage system. In contrast to other lysosomal storage disorders, skeletal involvement in NPD has not been
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