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Merck
CN
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文件

安全信息

S6545

Sigma-Aldrich

角蝰毒素S6c

≥97% (HPLC)

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别名:
SRTX-c
经验公式（希尔记法）:
C103H147N27O37S5
CAS号:
121695-87-2
分子量:
2515.75
MDL编号:
MFCD00161501
UNSPSC代码:
12352200
PubChem化学物质编号:
24899710
NACRES:
NA.32

质量水平

200

检测方案

≥97% (HPLC)

储存温度

−20°C

SMILES字符串

CCC(C)C(NC(=O)C(NC(=O)C(CC(O)=O)NC(=O)C(CCC(N)=O)NC(=O)C(Cc1cnc[nH]1)NC(=O)C2CSSCC(N)C(=O)NC(C(C)O)C(=O)NC3CSSCC(NC(=O)C(CCC(O)=O)NC(=O)C(CCC(O)=O)NC(=O)C(CC(O)=O)NC(=O)C(NC(=O)C(CCSC)NC(=O)C(CC(O)=O)NC(=O)C(CC(N)=O)NC3=O)C(C)O)C(=O)NC(CC(C)C)C(=O)NC(CC(N)=O)C(=O)NC(Cc4ccccc4)C(=O)N2)C(C)C)C(=O)NC(Cc5c[nH]c6ccccc56)C(O)=O

InChI

1S/C103H147N27O37S5/c1-10-46(6)80(100(163)123-67(103(166)167)30-50-37-109-54-19-15-14-18-52(50)54)128-99(162)79(45(4)5)127-95(158)66(36-78(144)145)120-85(148)55(20-23-71(105)133)112-90(153)61(31-51-38-108-43-110-51)117-97(160)69-40-170-169-39-53(104)83(146)129-81(47(7)131)102(165)126-70-42-172-171-41-68(96(159)115-59(28-44(2)3)88(151)118-62(32-72(106)134)91(154)116-60(89(152)125-69)29-49-16-12-11-13-17-49)124-86(149)57(22-25-75(138)139)111-84(147)56(21-24-74(136)137)113-94(157)65(35-77(142)143)122-101(164)82(48(8)132)130-87(150)58(26-27-168-9)114-93(156)64(34-76(140)141)121-92(155)63(33-73(107)135)119-98(70)161/h11-19,37-38,43-48,53,55-70,79-82,109,131-132H,10,20-36,39-42,104H2,1-9H3,(H2,105,133)(H2,106,134)(H2,107,135)(H,108,110)(H,111,147)(H,112,153)(H,113,157)(H,114,156)(H,115,159)(H,116,154)(H,117,160)(H,118,151)(H,119,161)(H,120,148)(H,121,155)(H,122,164)(H,123,163)(H,124,149)(H,125,152)(H,126,165)(H,127,158)(H,128,162)(H,129,146)(H,130,150)(H,136,137)(H,138,139)(H,140,141)(H,142,143)(H,144,145)(H,166,167)

InChI key

LXPHPKVWHQLBBA-UHFFFAOYSA-N

基因信息

human ... EDNRB(1910)
mouse ... EDNRB(13618)
rat ... EDNRB(50672)

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相关类别

Amino Acid Sequence

Cys-Thr-Cys-Asn-Asp-Met-Thr-Asp-Glu-Glu-Cys-Leu-Asn-Phe-Cys-His-Gln-Asp-Val-Ile-Trp [Disulfide Bridges: 1-15, 3-11]

生化/生理作用

Sarafotoxin S6c是一种内皮素ETB激动剂。它是一种从中东蛇Atractaspis engaddensi中获得并具有强血管收缩活性的肽类异毒素。该毒素由21个氨基酸组成。

其他说明

从0.1％TFA水溶液中冻干

象形图

Skull and crossbones
GHS06

警示用语：

Danger

危险声明

H300 + H330

危险分类

Acute Tox. 1 Inhalation - Acute Tox. 1 Oral

WGK

WGK 3

闪点(°F)

Not applicable

闪点(°C)

Not applicable

个人防护装备

Eyeshields, Gloves, type N95 (US)

法规信息

高风险级别生物产品--毒素类产品

分析证书(COA)

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Sarafotoxin S6c: an agonist which distinguishes between endothelin receptor subtypes.
Willaims DL Jr
Biochemical and Biophysical Research Communications (1991)
The ocular hypotensive effect of the ETB receptor selective agonist, sarafotoxin S6c, in rabbits
Haque MS
Investigative Ophthalmology & Visual Science (1995)
J L Marshall et al.
British journal of pharmacology, 128(3), 809-815 (1999-10-12)
1. An investigation was performed in pentobarbitone anaesthetized rats to compare the renal vasoconstrictor actions of endothelin-1 (ET-1), endothelin-3 (ET-3) and sarafotoxin 6c and their dependency on NO production. 2. Intra-renal arterial infusion of ET-1 and ET-3, from 1 -
D L Williams et al.
Biochemical and biophysical research communications, 175(2), 556-561 (1991-03-25)
In contrast to endothelin-1 (ET-1) and several of its analogues, sarafotoxin S6c (S6c) was a much more potent inhibitor of [125I]-ET-1 binding in rat hippocampus and cerebellum (Ki approximately 20 pM) than in rat atria and aorta (Ki approximately 4500
R J Johnson et al.
The Journal of pharmacology and experimental therapeutics, 289(2), 762-767 (1999-04-24)
In the present study, endothelin (ET) agonists and receptor selective antagonists were used to characterize ET receptors mediating constriction in guinea pig mesenteric veins (250-300 micrometers diameter) in vitro. The contribution of ET-evoked vasodilator release to venous tone was also

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