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Merck
CN
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文件

S6319

Sigma-Aldrich

盐酸舍曲林 盐酸盐

≥98% (HPLC)

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别名:
盐酸舍曲林, (1S,4S)-4-（3,4-二氯苯基）-1,2,3,4-四氢-N-甲基-1-萘胺 盐酸盐
经验公式（希尔记法）:
C17H17NCl2 · HCl
CAS号:
79559-97-0
分子量:
342.69
MDL编号:
MFCD00895772
UNSPSC代码:
12352200
PubChem化学物质编号:
24278601
NACRES:
NA.77

质量水平

100

检测方案

≥98% (HPLC)

形式

powder

旋光性

[α]/D +33 to +43°, c = 2.0 in methanol

储存条件

desiccated

颜色

white

溶解性

DMSO: >20 mg/mL

SMILES字符串

ClC1=C(Cl)C=CC([C@H]2C3=C(C=CC=C3)[C@@H](NC)CC2)=C1.[H]Cl

InChI

1S/C17H17Cl2N.ClH/c1-20-17-9-7-12(13-4-2-3-5-14(13)17)11-6-8-15(18)16(19)10-11;/h2-6,8,10,12,17,20H,7,9H2,1H3;1H/t12-,17-;/m0./s1

InChI key

BLFQGGGGFNSJKA-XHXSRVRCSA-N

基因信息

human ... HTR1A(3350) , HTR1B(3351) , HTR1D(3352) , HTR1E(3354) , HTR1F(3355) , HTR2A(3356) , HTR2B(3357) , HTR2C(3358) , HTR3A(3359) , HTR3B(9177) , HTR3C(170572) , HTR3D(200909) , HTR3E(285242) , HTR4(3360) , HTR5A(3361) , HTR5B(645694) , HTR6(3362) , HTR7(3363) , SLC6A4(6532)

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应用

在长期准备好的绵羊胎儿中研究了盐酸舍曲林暴露的影响。将其用于糖皮质激素功能测定，研究抗抑郁药对人体糖皮质激素受体功能的影响。

生化/生理作用

舍曲林抑制血小板功能，显示抗血小板和内皮保护功能。缓解抑郁症，提高心血管疾病患者的生活质量。 也可开处方治疗帕金森病的抑郁症状。
选择性 5-羟色胺再摄取抑制剂，抗抑郁药。

特点和优势

该化合物收录于 受体分类和信号转导手册的《生物胺转运体 》页面。想要浏览手册的其他页面， 请单击此处。
这种化合物是ADME毒性研究的特色产品。点击此处发现更多特色ADME毒性产品。在sigma.com/discover-bsm可了解更多关于生物活性小分子的其他研究领域。

警示用语：

Warning

危险声明

H302,H373,H410

危险分类

Acute Tox. 4 Oral - Aquatic Acute 1 - Aquatic Chronic 1 - STOT RE 2

WGK

WGK 3

闪点(°F)

Not applicable

闪点(°C)

Not applicable

个人防护装备

Eyeshields, Gloves, type N95 (US)

分析证书(COA)

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British journal of cancer, 128(10), 1862-1878 (2023-03-19)
One-third of cancers activate endogenous synthesis of serine/glycine, and can become addicted to this pathway to sustain proliferation and survival. Mechanisms driving this metabolic rewiring remain largely unknown. NKX2-1 overexpressing and NKX2-1 knockdown/knockout T-cell leukaemia and lung cancer cell line
Hannah P Fricke et al.
Frontiers in pharmacology, 14, 1244580-1244580 (2023-12-11)
Postpartum depression affects many individuals after parturition, and selective serotonin reuptake inhibitors (SSRIs) are often used as the first-line treatment; however, both SSRIs and lactation are independently associated with bone loss due to the role of serotonin in bone remodeling.
Cassidy Delaney et al.
American journal of physiology. Lung cellular and molecular physiology, 301(6), L937-L944 (2011-09-13)
Maternal use of selective serotonin (5-HT) reuptake inhibitors (SSRIs) is associated with an increased risk for persistent pulmonary hypertension of the newborn (PPHN), but little is known about 5-HT signaling in the developing lung. We hypothesize that 5-HT plays a
Rafael R Domingues et al.
Toxics, 10(1) (2022-01-21)
Selective serotonin reuptake inhibitors (SSRI) are the most common antidepressant used by pregnant women; however, they have been associated with adverse pregnancy outcomes and perinatal morbidity in pregnant women and animal models. We investigated the effects of two SSRI, fluoxetine
Hannah P Fricke et al.
Physiological reports, 11(23), e15881-e15881 (2023-11-30)
At the end of gestation, fetal skeleton rapidly accumulates calcium, and bone development continues in offspring postnatally. To accommodate, maternal skeletal physiology is modulated in a serotonin-dependent manner. Selective serotonin reuptake inhibitors (SSRIs) are generally considered safe for treatment of
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