S6319
盐酸舍曲林 盐酸盐
≥98% (HPLC), Selective serotonin reuptake inhibitor (SSRI), powder
别名:
盐酸舍曲林, (1S,4S)-4-（3,4-二氯苯基）-1,2,3,4-四氢-N-甲基-1-萘胺 盐酸盐
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关于此项目
经验公式（希尔记法）:
C17H17NCl2 · HCl
化学文摘社编号:
分子量:
342.69
UNSPSC Code:
12352200
PubChem Substance ID:
NACRES:
NA.77
MDL number:
产品名称
盐酸舍曲林 盐酸盐, ≥98% (HPLC)
Quality Level
assay
≥98% (HPLC)
form
powder
optical activity
[α]/D +33 to +43°, c = 2.0 in methanol
storage condition
desiccated
color
white
solubility
DMSO: >20 mg/mL
SMILES string
ClC1=C(Cl)C=CC([C@H]2C3=C(C=CC=C3)[C@@H](NC)CC2)=C1.[H]Cl
InChI
1S/C17H17Cl2N.ClH/c1-20-17-9-7-12(13-4-2-3-5-14(13)17)11-6-8-15(18)16(19)10-11;/h2-6,8,10,12,17,20H,7,9H2,1H3;1H/t12-,17-;/m0./s1
InChI key
BLFQGGGGFNSJKA-XHXSRVRCSA-N
Gene Information
Application
在长期准备好的绵羊胎儿中研究了盐酸舍曲林暴露的影响。将其用于糖皮质激素功能测定，研究抗抑郁药对人体糖皮质激素受体功能的影响。
Biochem/physiol Actions
舍曲林抑制血小板功能，显示抗血小板和内皮保护功能。缓解抑郁症，提高心血管疾病患者的生活质量。 也可开处方治疗帕金森病的抑郁症状。
选择性 5-羟色胺再摄取抑制剂，抗抑郁药。
Features and Benefits
该化合物收录于 受体分类和信号转导手册的《生物胺转运体 》页面。想要浏览手册的其他页面， 请单击此处。
这种化合物是ADME毒性研究的特色产品。点击此处发现更多特色ADME毒性产品。在sigma.com/discover-bsm可了解更多关于生物活性小分子的其他研究领域。
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signalword
Warning
hcodes
Hazard Classifications
Acute Tox. 4 Oral - Aquatic Acute 1 - Aquatic Chronic 1 - STOT RE 2
存储类别
11 - Combustible Solids
wgk
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
ppe
Eyeshields, Gloves, type N95 (US)
商品
Discover Bioactive Small Molecules for ADME/Tox
Rafael R Domingues et al.
Toxics, 10(1) (2022-01-21)
Selective serotonin reuptake inhibitors (SSRI) are the most common antidepressant used by pregnant women; however, they have been associated with adverse pregnancy outcomes and perinatal morbidity in pregnant women and animal models. We investigated the effects of two SSRI, fluoxetine
Hannah P Fricke et al.
Frontiers in pharmacology, 14, 1244580-1244580 (2023-12-11)
Postpartum depression affects many individuals after parturition, and selective serotonin reuptake inhibitors (SSRIs) are often used as the first-line treatment; however, both SSRIs and lactation are independently associated with bone loss due to the role of serotonin in bone remodeling.
Elien Heylen et al.
British journal of cancer, 128(10), 1862-1878 (2023-03-19)
One-third of cancers activate endogenous synthesis of serine/glycine, and can become addicted to this pathway to sustain proliferation and survival. Mechanisms driving this metabolic rewiring remain largely unknown. NKX2-1 overexpressing and NKX2-1 knockdown/knockout T-cell leukaemia and lung cancer cell line
全球贸易项目编号
| 货号 | GTIN |
|---|---|
| S6319-10MG | 04061836957872 |
| S6319-50MG | 04061836957889 |