形式
lyophilized powder
质量水平
比活
25,000-50,000 U/vial
分子量
native 69 kDa
组成
Protein, ~3% Lowry
储存条件
(Keep container tightly closed in a dry and well-ventilated place. Keep in a dry place.)
颜色
white
溶解性
H2O: soluble 1 mg/mL
抗生素抗菌谱
neoplastics
作用机制
cell membrane | interferes
储存温度
2-8°C
基因信息
Streptococcus pyogenes MGAS8232 ... slo(993428)
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应用
用于在富含胆固醇的细胞质膜上穿孔（可逆穿孔），使蛋白质（高达100 kDa)和siRNA等分子可以选择性透膜。
链球菌溶血素O(Streptolysin O)是化脓性链球菌(Streptococcus pyogenes)分泌的毒素，是成孔细菌溶细胞素的原型成员。 用于穿透细胞膜，便于细胞摄取大分子或带电分子。 可用于研究大分子运输。 作为潜在抗癌药，可用于研究自杀基因癌症治疗。
透膜允许细胞摄取大分子或带电分子。
生化/生理作用
能穿透动物细胞膜的巯基活化毒素。该蛋白作为单体与膜胆固醇结合，随后聚合成围绕>12 nm孔的大弧形和环形结构。
链球菌溶血素O由分子量为62 kDa的单条多肽链组成。 链球菌溶血素O可结合细胞膜胆固醇，并聚合形成含45-50个单体的环形结构。 环结构插入膜中形成一个可供DNA、RNA、肽和蛋白分子通过的大孔洞（25-30nm）。 硫醇活化。 受大蒜活性成分——大蒜素(Allicin)抑制。
包装
25KU
单位定义
一单位将导致2%红细胞悬液在磷酸缓冲液(pH 7.4)中37 °C孵育30 min后发生50%溶解。
外形
含Tris缓冲盐、叠氮化钠、PMSF和EDTA的冻干粉末。
其他说明
保存于密闭容器内，置于干燥通风处。置于干燥处保存。
警示用语：
Danger
危险分类
Acute Tox. 2 Dermal - Acute Tox. 2 Inhalation - Acute Tox. 2 Oral - Aquatic Chronic 2 - Eye Dam. 1 - Skin Irrit. 2
WGK
WGK 3
闪点(°F)
Not applicable
闪点(°C)
Not applicable
个人防护装备
Eyeshields, Gloves, type N95 (US)
法规信息
高风险级别生物产品--毒素类产品
Neurotransmitter interactions related to central dopamine neurons.
K G Lloyd
Essays in neurochemistry and neuropharmacology, 3, 129-207 (1978-01-01)
Chen Chen et al.
Nanoscale, 10(11), 5154-5162 (2018-03-02)
Exosomes are small membrane vesicles secreted by a wide variety of cells. Studies have demonstrated that exosomal miRNAs can influence the biological processes of recipient cells. Therefore, direct imaging and tracking of exosomal miRNAs in living recipient cells are essential
Wan Seok Yang et al.
Molecular cancer therapeutics, 5(6), 1610-1619 (2006-07-05)
We cloned the streptolysin O gene from the Streptococcus pyogenes genome and tested the possibility of using it as an anticancer reagent. Transient transfection of the streptolysin O gene efficiently killed 293T cells after 12 hours of transfection as determined
John Popovich et al.
Frontiers in bioengineering and biotechnology, 8, 527-527 (2020-06-26)
Pore-forming and hemolytic toxins are bacterial cytotoxic proteins required for virulence in many pathogens, including staphylococci and streptococci, and are notably associated with clinical manifestations of disease. Inspired by adsorption properties of naturally occurring aluminosilicates, we engineered inexpensive, laboratory-synthesized, aluminosilicate
Stefanie Klar et al.
Journal of occupational medicine and toxicology (London, England), 16(1), 32-32 (2021-08-14)
Workers of agriculture and intensive life stock farming are exposed to highly contaminated workplaces. Bioaerosol exposures are suspected to trigger respiratory health effects of the workers. So far, risk evaluation of bioaerosols has been assessed through the infectivity of comprising
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