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Merck
CN
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安全信息

S3672

Sigma-Aldrich

[Sar9, Met(O2)11]-Substance P

≥95% (HPLC)

别名:

Arg-Pro-Lys-Pro-Gln-Gln-Phe-Phe-Sar-Leu-Met[O2]-NH2

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About This Item

经验公式（希尔记法）:
C64H100N18O15S
CAS号:
110880-55-2
分子量:
1393.66
MDL编号:
MFCD00076787
UNSPSC代码:
12352209
PubChem化学物质编号:
24899567
NACRES:
NA.32

质量水平

100

方案

≥95% (HPLC)

储存温度

−20°C

SMILES字符串

CC(C)CC(NC(=O)CN(C)C(=O)C(Cc1ccccc1)NC(=O)C(Cc2ccccc2)NC(=O)C(CCC(N)=O)NC(=O)C(CCC(N)=O)NC(=O)C3CCCN3C(=O)C(CCCCN)NC(=O)C4CCCN4C(=O)C(N)CCCNC(N)=N)C(=O)NC(CCS(C)(=O)=O)C(N)=O

InChI

1S/C64H100N18O15S/c1-38(2)34-46(57(89)74-42(54(69)86)28-33-98(4,96)97)73-53(85)37-80(3)62(94)48(36-40-18-9-6-10-19-40)79-58(90)47(35-39-16-7-5-8-17-39)78-56(88)43(24-26-51(67)83)75-55(87)44(25-27-52(68)84)76-59(91)50-23-15-32-82(50)63(95)45(21-11-12-29-65)77-60(92)49-22-14-31-81(49)61(93)41(66)20-13-30-72-64(70)71/h5-10,16-19,38,41-50H,11-15,20-37,65-66H2,1-4H3,(H2,67,83)(H2,68,84)(H2,69,86)(H,73,85)(H,74,89)(H,75,87)(H,76,91)(H,77,92)(H,78,88)(H,79,90)(H4,70,71,72)

InChI key

OUPXSLGGCPUZJJ-UHFFFAOYSA-N

基因信息

human ... TACR1(6869)
mouse ... TACR1(21336)
rat ... TACR1(24807)

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Amino Acid Sequence

Arg-Pro-Lys-Pro-Gln-Gln-Phe-Phe-Sar-Leu-Met[O]2-NH2

生化/生理作用

Highly selective NK-1 receptor agonist.

储存分类代码

11 - Combustible Solids

WGK

WGK 3

闪点(°F)

Not applicable

闪点(°C)

Not applicable

个人防护装备

Eyeshields, Gloves, type N95 (US)

法规信息

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分析证书(COA)

Lot/Batch Number
BCCM4183
BCCK6680
BCCC2830
BCBV4760
BCBQ9274V

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Takayuki Endoh
Brain research, 1110(1), 116-127 (2006-07-29)
Neurokinins, such as substance P (SP), modulate the reflex regulation of cardiovascular and respiratory function in the CNS, particularly in the nucleus tractus solitarius (NTS). There is considerable evidence of the action of SP in the NTS, but the precise
Angelina Y Fong et al.
The Journal of physiology, 575(Pt 3), 869-885 (2006-07-11)
In the present study, we examined the role of the neurokinin-1 receptor (NK1R) in the modulation of respiratory rhythm in a functionally identified bradypnoeic region of the ventral respiratory group (VRG) in the in situ arterially perfused juvenile rat preparation.
Arvind K Chappa et al.
Pharmaceutical research, 23(6), 1201-1208 (2006-05-27)
Substance P (SP; NH3(+)-Arg(+)-Pro-Lys(+)-Pro-Gln-Gln-Phe-Phe-Gly-Leu-Met-NH2) belongs to a group of neurokinins that are widely distributed in the central nervous system and peripheral nervous system. The biological effects mediated by SP in the central nervous system include regulation of affective behavior, emesis
Qiao-Ling Cui et al.
The European journal of neuroscience, 26(7), 1853-1861 (2007-09-18)
Substance P is a member of the neurokinin family. Previous studies have reported the existence of substance P and its high-affinity receptor, neurokinin-1 receptor, in globus pallidus. Employing in vivo extracellular recording combined with behavioural tests, the effects of substance
Judy Zhu et al.
Journal of neurochemistry, 111(3), 656-668 (2009-08-18)
In a previous study we showed that pharmacological blockade of the neurokinin-1 receptors attenuated the methamphetamine (METH)-induced toxicity of the striatal dopamine terminals. In the present study we examined the role of the neurokinin-1 receptors on the METH-induced apoptosis of
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