所有图片(1)
About This Item
经验公式（希尔记法）:
C16H14N3O3Cl
CAS号:
分子量:
331.75
MDL编号:
UNSPSC代码:
12352200
PubChem化学物质编号:
NACRES:
NA.77
质量水平
检测方案
≥98% (HPLC)
形式
solid
颜色
white
mp
190-191 °C (lit.)
溶解性
DMSO: soluble 10 mg/mL
H2O: insoluble
SMILES字符串
CC(=O)NNC(=O)N1Cc2ccccc2Oc3ccc(Cl)cc13
InChI
1S/C16H14ClN3O3/c1-10(21)18-19-16(22)20-9-11-4-2-3-5-14(11)23-15-7-6-12(17)8-13(15)20/h2-8H,9H2,1H3,(H,18,21)(H,19,22)
InChI key
KNURFLJTOUGOOQ-UHFFFAOYSA-N
基因信息
human ... PTGER1(5731)
rat ... Ptger1(25637)
应用
采用 SC 19220 研究前列腺素 E 2 在大鼠皮质培养物中氧糖剥夺诱导的神经毒性和预处理诱导的神经保护中的作用。
生化/生理作用
SC 19220 是前列腺素 E 受体的竞争性拮抗剂。它与 PGE 2 竞争调节膀胱尿道运动，并增加大鼠膀胱容量。它能抑制平滑肌对前列腺素 E 2 和 F 2α 的收缩反应。SC 19220 还可抑制维生素 D3、甲状旁腺激素、IL-11 和 IL-6 诱导的破骨细胞的形成。
EP 1 前列腺素受体拮抗剂
WGK
WGK 3
闪点(°F)
Not applicable
闪点(°C)
Not applicable
个人防护装备
Eyeshields, Gloves, type N95 (US)
H Inoue et al.
The Journal of endocrinology, 161(2), 231-236 (1999-05-13)
1,25 Dihydroxy vitamin D3 (1,25(OH)2D3), prostaglandin (PG) E2 and parathyroid hormone (PTH) induce osteoclast formation in cell cultures. Previously, we have shown that SC-19220, an antagonist of the EP1 subtype of PGE receptors, inhibited tartrate-resistant acid phosphatase (TRAP)-positive cell formation
Alexander V Timoshenko et al.
Experimental cell research, 289(2), 265-274 (2003-09-23)
Aberrant upregulation of COX-2 enzyme resulting in accumulation of PGE2 in a cancer cell environment is a marker for progression of many cancers, including breast cancer. Four subtypes of cell surface receptors (EP1, EP2, EP3, and EP4), which are coupled
L Walch et al.
British journal of pharmacology, 134(8), 1671-1678 (2001-12-12)
1. To characterize the prostanoid receptors (TP, FP, EP(1) and/or EP(3)) involved in the vasoconstriction of human pulmonary veins, isolated venous preparations were challenged with different prostanoid-receptor agonists in the absence or presence of selective antagonists. 2. The stable thromboxane
K Oka et al.
The American journal of physiology, 275(6 Pt 2), R1762-R1765 (1998-12-09)
We have previously reported that central injection of PGE2 induces hyperthermia through its actions on EP1 receptors in rats. Because the increase in local synthesis of PGE2 is assumed to be a necessary process in a fever caused by central
S Santangelo et al.
The Journal of trauma, 48(5), 826-830 (2000-05-24)
Although prostaglandin E2 (PGE2) has been shown to be immunosuppressive, its role in the development of specific bone marrow myeloid lineages after thermal injury and sepsis has yet to be elucidated. The purpose of this study was to demonstrate that
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