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S2812

SNC80

Name: SNC80
Brand: SIGMA

≥98% (HPLC), δ opioid receptor agonist, solid

别名:

(+)-4-[(αR)-α-((2S,5R)-4-烯丙基-2,5-二甲基-1-哌嗪基)-3-甲氧基苄基]-N,N-二乙基苯甲酰胺, SNC 80, SNC-80

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关于此项目

经验公式（希尔记法）:

C₂₈H₃₉N₃O₂

化学文摘社编号:

156727-74-1

分子量:

449.63

UNSPSC Code:

12352200

PubChem Substance ID:

24278698

NACRES:

NA.77

MDL number:

MFCD00672673

Assay:

≥98% (HPLC)

Form:

solid

Quality level:

100

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属性

产品名称

SNC80, ≥98% (HPLC), solid

Quality Level

100

assay

≥98% (HPLC)

form

solid

color

off-white

solubility

DMSO: soluble

SMILES string

CCN(CC)C(=O)c1ccc(cc1)[C@H](N2C[C@H](C)N(CC=C)C[C@H]2C)c3cccc(OC)c3

InChI

1S/C28H39N3O2/c1-7-17-30-19-22(5)31(20-21(30)4)27(25-11-10-12-26(18-25)33-6)23-13-15-24(16-14-23)28(32)29(8-2)9-3/h7,10-16,18,21-22,27H,1,8-9,17,19-20H2,2-6H3/t21-,22+,27?/m0/s1

InChI key

KQWVAUSXZDRQPZ-QNWUEUMSSA-N

Gene Information

human ... OPRD1(4985)
mouse ... Oprd1(18386)
rat ... Oprd1(24613), Oprm1(25601)

说明

Application

给予大鼠SNC80以研究一氧化氮合酶在外周抗伤害感受机制中的作用。⁵

Biochem/physiol Actions

SNC80是δ-阿片受体激动剂。

SNC80是δ阿片受体的高度选择性激动剂，但也与μ-δ阿片受体异聚体结合以在小鼠中产生镇痛作用。²它还充当抗抑郁药³，引起多巴胺相关行为并增强对精神刺激药的行为反应。⁴

Features and Benefits

《受体分类和信号转导》手册的阿片类药物受体页有该化合物的介绍。想要浏览手册的其他页面，请单击此处。

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存储类别

11 - Combustible Solids

wgk

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

ppe

Eyeshields, Gloves, type N95 (US)

历史批次信息供参考:

分析证书(COA)

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Novel screening assay for the selective detection of G-protein-coupled receptor heteromer signaling.

Richard M van Rijn et al.

The Journal of pharmacology and experimental therapeutics, 344(1), 179-188 (2012-10-26)

Drugs targeting G-protein-coupled receptors (GPCRs) make up more than 25% of all prescribed medicines. The ability of GPCRs to form heteromers with unique signaling properties suggests an entirely new and unexplored pool of drug targets. However, current in vitro assays

The development of a mouse model of mTBI-induced post-traumatic migraine, and identification of the delta opioid receptor as a novel therapeutic target.

Laura S Moye et al.

Cephalalgia : an international journal of headache, 39(1), 77-90 (2018-05-18)

Post-traumatic headache is the most common and long-lasting impairment observed following mild traumatic brain injury, and frequently has migraine-like characteristics. The mechanisms underlying progression from mild traumatic brain injury to post-traumatic headache are not fully understood. The aim of this

The novel δ opioid receptor agonist KNT-127 produces antidepressant-like and antinociceptive effects in mice without producing convulsions.

Akiyoshi Saitoh et al.

Behavioural brain research, 223(2), 271-279 (2011-05-14)

We previously reported that the δ opioid receptor (DOP) agonists SNC80 and TAN-67 produce potent antidepressant-like and antinociceptive effects in rodents. However, SNC80 produced convulsive effects. Recently, we succeeded in synthesizing a novel DOP agonist called KNT-127. The present study

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全球贸易项目编号

货号	GTIN
S2812-5MG	04061832559575
S2812-25MG	04061832559568