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质量水平
方案
≥98% (HPLC)
表单
lyophilized powder
颜色
white
UniProt登记号
储存温度
−20°C
SMILES字符串
OC(=O)C(F)(F)F.CC(C)C[C@H](NC(=O)[C@H](CC(C)C)NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@@H](N)CO)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](CC(N)=O)C(N)=O
InChI
1S/C34H57N11O8.C2HF3O2/c1-18(2)13-24(31(51)41-22(11-8-12-40-34(38)39)30(50)42-23(28(37)48)16-27(36)47)44-32(52)25(14-19(3)4)45-33(53)26(43-29(49)21(35)17-46)15-20-9-6-5-7-10-20;3-2(4,5)1(6)7/h5-7,9-10,18-19,21-26,46H,8,11-17,35H2,1-4H3,(H2,36,47)(H2,37,48)(H,41,51)(H,42,50)(H,43,49)(H,44,52)(H,45,53)(H4,38,39,40);(H,6,7)/t21-,22-,23-,24-,25-,26-;/m0./s1
InChI key
YICKZNIVMKPQPD-POCCEKOUSA-N
基因信息
human ... IGF1R(3480)
Amino Acid Sequence
Ser-Phe-Leu-Leu-Arg-Asn-NH2
应用
Ser-Phe-Leu-Leu-Arg-Asn-酰胺三氟乙酸盐可作为蛋白酶激活受体1(PAR-1)特异性激动剂肽。
生化/生理作用
Ser-Phe-Leu-Leu-Arg-Asn-酰胺三氟乙酸盐(SFLLRN)可作为蛋白酶激活受体1(PAR-1)特异性激动剂肽。
凝血酶受体激活肽(TRAP)。
储存分类代码
11 - Combustible Solids
WGK
WGK 3
闪点(°F)
Not applicable
闪点(°C)
Not applicable
个人防护装备
Eyeshields, Gloves, type N95 (US)
法规信息
常规特殊物品
历史批次信息供参考:
Vox sanguinis, 111(3), 247-256 (2016-10-22)
In mice, loss of sialic acid resulting in shedding of glycoprotein (GP) Ibα and GPV has been linked to platelet survival. The aim of this study was to determine whether loss of sialic acid and the GPIb-IX-V complex contributes to
Hippocampus, 24(8), 1030-1038 (2014-04-23)
Thrombin and other clotting factors regulate long-term potentiation (LTP) in the hippocampus through the activation of the protease activated receptor 1 (PAR1) and consequent potentiation of N-methyl-d-aspartate receptor (NMDAR) functions. We have recently shown that the activation of PAR1 either
Amino Acids, Peptides and Proteins, 29 (1998)
Thrombin induces Ca2+-dependent glutamate release from RPE cells mediated by PLC/PKC and reverse Na+/Ca2+ exchange
Molecular Vision (2019)
Molecular pharmacology, 91(1), 39-47 (2016-10-28)
Human platelets display a unique dual receptor system for responding to its primary endogenous activator, α-thrombin. Because of the lack of efficacious antagonists, the field has relied on synthetic peptides and pepducins to describe protease-activated receptor PAR1 and PAR4 signaling.
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