S1688
SR 57227A
solid
别名:
4-amino-1-(6-chloro-2-pyridyl)-piperidine hydrochloride
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关于此项目
经验公式（希尔记法）:
C10H14ClN3 · HCl
化学文摘社编号:
分子量:
248.15
NACRES:
NA.77
PubChem Substance ID:
UNSPSC Code:
12352200
MDL number:
Form:
solid
Quality level:
产品名称
SR 57227A, solid
InChI
1S/C10H14ClN3.ClH/c11-9-2-1-3-10(13-9)14-6-4-8(12)5-7-14;/h1-3,8H,4-7,12H2;1H
SMILES string
Cl.NC1CCN(CC1)c2cccc(Cl)n2
InChI key
FUMINTAAUJUVMP-UHFFFAOYSA-N
form
solid
color
white
solubility
H2O: soluble 9 mg/mL
Quality Level
Gene Information
human ... HTR3A(3359), HTR3B(9177), HTR3C(170572), HTR3D(200909), HTR3E(285242)
相关类别
Application
SR 57227A may be used in 5-HT3-mediated cell signaling studies.
Biochem/physiol Actions
Potent and selective 5-HT3 serotonin receptor agonist.
SR 57227A is a highly selective of central and peripheral 5-HT3 receptors and an inhibitor of NMDA receptor-mediated responses in rat cortical pyramidal cells. It exhibits anti-depressant like effects in rats and decreased isolation-induced aggressive behavior.
signalword
Danger
hcodes
Hazard Classifications
Acute Tox. 3 Oral - Eye Irrit. 2 - Skin Irrit. 2 - STOT SE 3
target_organs
Respiratory system
存储类别
6.1C - Combustible acute toxic Cat.3 / toxic compounds or compounds which causing chronic effects
wgk
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
ppe
Eyeshields, Faceshields, Gloves, type P2 (EN 143) respirator cartridges
Qiao Jun Zhang et al.
Brain research, 1384, 69-79 (2011-02-05)
In the present study, effect of SR 57227A, a selective 5-hydroxytryptamine-3 (5-HT(3)) receptor agonist, on the firing activity of pyramidal neurons in the medial prefrontal cortex (mPFC) was studied in normal rats and rats with 6-hydroxydopamine lesions of the substantia
Taha Gholipour et al.
Seizure, 19(1), 17-22 (2009-11-28)
There is some evidence that epileptic seizures could be induced or increased by 5-hydroxytryptamine (5-HT) attenuation, while augmentation of serotonin functions within the brain (e.g. by SSRIs) has been reported to be anticonvulsant. This study was performed to determine the
M Poncelet et al.
Journal of neural transmission. General section, 102(2), 83-90 (1995-01-01)
We have investigated the effect of SR 57227A, a selective 5-HT3 receptor agonist which crosses the blood brain barrier, on three rodent models in which antidepressants are active. In the forced swimming test, SR 57227A dose-dependently reduced the duration of
Heba Abdel-Aziz et al.
European journal of pharmacology, 530(1-2), 136-143 (2005-12-21)
Ginger (rhizomes of Zingiber officinale) has been shown to exert potent anti-emetic properties, but its mode of action has not yet been elucidated. Among its active constituents, [6]-, [8]- and [10]-gingerol as well as [6]-shogaol were shown in different in
Z H Gui et al.
Neuroscience, 169(3), 1315-1325 (2010-06-26)
In the present study, we examined changes in the firing rate and firing pattern of putative slow-spiking (SS) and fast-spiking (FS) interneurons in medial prefrontal cortex (mPFC) and the effect of 5-hydroxytryptamine-3 (5-HT(3)) receptor agonist SR 57227A on the neuronal
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