S166
Saclofen
solid
别名:
β-（氨甲基）-4-氯苯乙磺酸
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关于此项目
经验公式（希尔记法）:
C9H12ClNO3S
化学文摘社编号:
分子量:
249.71
NACRES:
NA.32
PubChem Substance ID:
UNSPSC Code:
51111800
MDL number:
Form:
solid
Quality level:
form
solid
Quality Level
color
white
solubility
0.1 M NaOH: 20 mg/mL
SMILES string
NCC(CS(O)(=O)=O)c1ccc(Cl)cc1
InChI
1S/C9H12ClNO3S/c10-9-3-1-7(2-4-9)8(5-11)6-15(12,13)14/h1-4,8H,5-6,11H2,(H,12,13,14)
InChI key
JYLNVJYYQQXNEK-UHFFFAOYSA-N
Gene Information
human ... GABBR1(2550), GABBR2(9568)
mouse ... GABBR1(54393), GABBR2(242425)
rat ... GABBR1(81657), GABBR2(83633)
Application
使用Saclofen作为GABAB受体拮抗剂以研究大鼠反复注射羟考酮的镇痛作用。
Saclofen已被用于阻止催产素对辣椒素诱导的谷氨酸自发兴奋性传递的抑制作用。
Biochem/physiol Actions
Saclofen是巴氯芬的磺酸类似物，是一种选择性GABAB受体拮抗剂。
Saclofen可能具有交感神经系统依赖性抗炎作用。
存储类别
11 - Combustible Solids
wgk
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
ppe
Eyeshields, Gloves, type N95 (US)
Mahinda Kommalage et al.
European journal of pharmacology, 525(1-3), 69-73 (2005-11-22)
It has been shown that analgesics such as morphine, lidocaine and clonidine increase the release of spinal acetylcholine. Acetylcholine may therefore play an important role in the regulation of spinal pain threshold. Since behavioral as well as in vitro studies
Cord Blood-Derived Neurons Are Originated from CD133+/CD34 Stem/Progenitor Cells in a Cell-to-Cell Contact Dependent Manner
Vincent Z
Stem Cells and Development (2005)
Gabriel S Bassi et al.
Naunyn-Schmiedeberg's archives of pharmacology, 389(8), 851-861 (2016-04-24)
Recent studies have demonstrated that the central nervous system controls inflammatory responses by activating complex efferent neuroimmune pathways. The present study was designed to evaluate the role that central gamma-aminobutyric acid type B (GABA-B) receptor plays in neutrophil migration in
Faraz Mahdian Dehkordi et al.
The Korean journal of pain, 32(3), 160-167 (2019-07-02)
Pain is a complex mechanism which involves different systems, including the opioidergic and GABAergic systems. Due to the side effects of chemical analgesic agents, attention toward natural agents have been increased. Artemisinin is an herbal compound with widespread modern and
Eisuke Koya et al.
Neuropharmacology, 56 Suppl 1, 177-185 (2008-06-21)
Cue-induced drug-seeking in rodents progressively increases after withdrawal from cocaine, suggesting that cue-induced cocaine craving incubates over time. Here, we explored the role of the medial prefrontal cortex (mPFC, a brain area previously implicated in cue-induced cocaine seeking) in this
全球贸易项目编号
| 货号 | GTIN |
|---|---|
| SAB5701894-100UL | 04065267678719 |
| SAB5700317-100UL | 04065265172622 |
| SAB5701958-100UL | 04065267679358 |
| S166-5MG | 04061836912925 |
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